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Lara C. Pullen, PhD

Lara C. Pullen, PhD, is a medical writer with a PhD in microbiology/immunology from Northwestern University’s Feinberg School of Medicine. As a medical writer she has covered topics as diverse as diabetes, cardiovascular disease, and autism. Her favorite subject, however, is the role of the immune system in health and disease. Dr. Pullen is also the mother of three children, the youngest of whom has Prader-Willi Syndrome (PWS). She is an active member of the PWS community and a thought leader on the importance of the ketogenic diet for this patient population.

Articles by Lara C. Pullen, PhD

BAFF: A Fulcrum Between Resistance to Infection & Autoimmunity

Lara C. Pullen, PhD  |  May 31, 2017

New research has linked a TNFSF13B variant and B cell activating factor (BAFF), a common therapeutic target, with multiple sclerosis and systemic lupus erythematosus. The variant is a disease-risk allele associated with increased levels of soluble BAFF…

Histamine 4 Receptor Promotes Osteoclastogenesis in RA

Lara C. Pullen, PhD  |  May 22, 2017

In a recent study, researchers examined the osteoclastogenic role of the histamine 4 receptor (H4R), measuring the peripheral blood and synovial fluid monocytes in patients with RA. Results showed that multiple cytokines stimulated H4R expression, suggesting the blockage of H4R may be a useful drug target to decrease the joint damage associated with RA…

Pregabalin Is Ineffective for Sciatica

Lara C. Pullen, PhD  |  May 8, 2017

A recent small-scale study examined the efficacy of pregabalin in the treatment of neuropathic pain caused by sciatica, as well as its associated low back pain. Researchers found the treatment did not reduce leg pain better than placebo and resulted in more adverse events…

MicroRNAs Provide Insight into Bone Metabolism

Lara C. Pullen, PhD  |  May 1, 2017

A recent study examined the functional variants within microRNAs that affect bone metabolism and possibly bone disorders. Researchers found overexpression of microRNAs may contribute to the osteoporotic phenotype, and the gene targets associated with two specific osteoblast-expressed microRNAs may be critical in osteoporosis…

Plasma Complement Activation in Rheumatic Diseases May Accelerate Coronary Artery Disease

Lara C. Pullen, PhD  |  April 24, 2017

A recent study examined the relationship between complement activation and coronary artery disease in patients with rheumatic disease. Researchers found these patients had higher plasma terminal complement complexes and more complement activation in the vascular adventitia, which may accelerate cardiovascular disease and act as a target for new therapies…

The Role of T Cells in Celiac Disease

Lara C. Pullen, PhD  |  April 17, 2017

Celiac is an autoimmune disease with both gastrointestinal and neurological implications. A recent review examined the immunological research on celiac disease to date, detailing the role of T cells and the protein TG2 in disease pathology…

Improved Diagnosis of Greater Trochanteric Pain Syndrome

Lara C. Pullen, PhD  |  April 10, 2017

New research evaluated the diagnostic accuracy of 10 clinical tests of hip pathology typically used to diagnosis greater trochanteric pain syndrome (GTPS). However, pain provocation tests, such as the FABER test, proved most useful for ruling out the condition rather than diagnosing it…

Brain Stimulation May Help with Fibromyalgia

Lara C. Pullen, PhD  |  April 3, 2017

New research examined the use of transcranial direct current stimulation over the dorsolateral prefrontal cortex of the brain to modulate attention in patients with fibromyalgia. The study found that the active current increased heat pain threshold and tolerance. However, a regression analysis showed the effect on executive attention appeared to be independent of the effect on pain…

Alterations in the Microbiome Are Associated with Changes in Bone Quality

Lara C. Pullen, PhD  |  March 28, 2017

By treating mice with antibiotics, researchers found that alterations in the gut microbiome impaired the mechanical properties of bone and depleted splenic B and T cell populations. The researchers suspect the decrease in bone strength resulted from the change in the immune system…

New NICE Guidance for Low Back Pain

Lara C. Pullen, PhD  |  March 20, 2017

If left untreated, low back pain can cause long-term disability. To aid its diagnosis and management, the National Institute for Health and Care Excellence has released revised guidance. Recommendations include the use of risk stratification tools for diagnosis, as well as physical activity or a comprehensive program that addresses biomechanical, aerobic and/or psychological needs…

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