NEW YORK (Reuters Health)—Treating inflammatory bowel disease (IBD) with tumor necrosis factor (TNF) inhibitors is associated with a doubling of the risk of central nervous system demyelinating disease, researchers from Denmark report. “Based on the current evidence anti-TNF should be used cautiously in patients with an own or family history of demyelinating disease,” Dr. Nynne…
Rheumatoid Arthritis Patients Have More Severe ACS, Poorer Outcomes
NEW YORK (Reuters Health)—Rheumatoid arthritis (RA) is associated with more-severe acute coronary syndrome and poorer outcomes, according to a new study. “We found that despite the well-researched increased risk of acute coronary events (ACS) in RA, that there was almost no existing data describing clinical characteristics and outcomes of RA- and non-RA patients with ACS,”…
Bone Loss Common in Suspected Spondyloarthritis
NEW YORK (Reuters Health)—More than 40% of patients with early inflammatory back pain suggestive of axial spondyloarthritis (SpA) show bone loss over the course of two years, according to French researchers. SpA is known to be associated with bone loss at the spine and the hip and an increased risk of vertebral fractures. To investigate…
Psoriasis Tied to Increased Risk of Major Depression
NEW YORK (Reuters Health)—People with psoriasis are twice as likely as others to have major depression, according to data from the National Health and Nutrition Examination Survey (NHANES). In earlier work, psoriasis has been linked to depression, anxiety and substance abuse. Studies have shown that both depression and psoriasis are associated with cardiovascular disease, which…
Immunotherapy May Be Effective for Some Patients with Autoimmune Cerebellar Ataxia
NEW YORK (Reuters Health)—Immunotherapy appears to yield neurological improvements in some patients with autoimmune cerebellar ataxia, especially those with nonparaneoplastic disorders, researchers report. “I was surprised that so many patients responded to immunotherapy (steroids, intravenous immunoglobulin (IVIg), and plasma exchange) and remained ambulatory,” Dr. Andrew McKeon from Mayo Clinic in Rochester, Minn., told Reuters Health…
Tabalumab Modestly Effective in Systemic Lupus Erythematosus
NEW YORK (Reuters Health)—Tabalumab, a monoclonal antibody to B-cell activating factor, was modestly better than placebo in relieving symptoms of systemic lupus erythematosus (SLE), according to results from the ILLUMINATE-2 trial. “Lupus is a complicated disease that does not behave the same way in all patients who share the clinical symptoms,” Dr. Joan T. Merrill…
How Hospitals Rank in Treating Childhood-Onset SLE
A recent study of how medical facilities in three countries meet minimum care standards for patients with childhood-onset systemic lupus erythematosus found a wide variation in quality of care…
Does Insomnia in Patients with Knee OA Affect Pain?
New research explores the correlation between insomnia and pain in patients with knee osteoarthritis (OA). After conducting a multimodal sleep study, researchers from Johns Hopkins University in Baltimore uncovered a combined effect between catastrophizing and disturbed sleep, resulting in increased pain sensitivity, specifically central sensitization, for knee OA…
Weight-Bearing Exercise Eases Knee Osteoarthritis, Temporarily
(Reuters Health)—A program of weight-bearing exercise reduces pain and improves joint function, at least for two to six months, for people with osteoarthritis, according to a review of previous trials. “We had a systematic review for Cochrane from 2008 and 2009, but there were much less articles,” said Dr. Martin Van der Esch, who coauthored…
Patients May Be Right: Tomatoes May Trigger Gout Flares
Dietary triggers of gout flares are associated with high levels of serum urate. A study recently uncovered an association between high serum urate and tomatoes, the first such link established beyond patient anecdotes…
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