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Systemic Lupus Erythematosus

2020 Pediatric Rheumatology Research in Review

Carina Stanton  |  November 24, 2020

ACR CONVERGENCE 2020—This has been a busy year for research publications covering a number of pediatric rheumatic diseases, including the emerging multi-system inflammatory syndrome (MIS-C) associated with SARS CoV-2. Despite the many challenges brought about by the COVID-19 pandemic, a healthy collection of publications covering a wide range of pediatric rheumatology research topics were published…

ACR Convergence 2020

Treatment of Lupus Nephritis Continues to See Progress

Thomas R. Collins  |  November 23, 2020

Three doctors reported on advances in research & treatments for lupus nephritis.

State of the Art Session Reviews Lupus Causes, Potential Treatments

Vanessa Caceres  |  November 20, 2020

ACR CONVERGENCE 2020—Rheumatologists and patients have struggled with a lack of new therapies for systemic lupus erythematosus (SLE), but a better understanding of the underlying mechanisms behind the disease helps shed light on potential treatments. That was the theme of the ACR Convergence session State of the Art: Lupus—The Future Is Now, led by Peggy…

Top Research in Lupus Presented at ACR Convergence 2020

David S. Pisetsky, MD, PhD  |  November 20, 2020

ACR CONVERGENCE 2020—Held Nov. 5–9, the ACR’s first fully virtual annual meeting is a wrap, but that doesn’t mean it’s too late to catch the highlights. Dozens of research abstracts on various aspects of lupus were presented during the fully virtual event, and David S. Pisetsky, MD, PhD, professor of medicine and immunology at Duke…

Synopsis: Single Cell Technologies & New Insights into SLE

Lara C. Pullen, PhD  |  November 16, 2020

ACR CONVERGENCE 2020—The definition of cell type depends increasingly on a cell’s molecular features. On Friday, Nov. 6, 2020, Alex Kuo, PhD, senior scientist at Stanford University School of Medicine, Stanford, Calif., described six technologies that are relatively mature and can be used for rheumatic disease research: Rapidly developing single-cell RNA sequencing (scRNA-seq); Cellular indexing…

Food for Thought: On Eating & Inflammation in Rheumatic Disease

Susan Bernstein  |  November 14, 2020

Certain nutrients or dietary patterns may affect inflammation and rheumatic disease risk in certain populations. Recommended nutrients include omega-3 fatty acids found in fish, poultry or nuts. Following a Mediterranean or standard Western diet may affect RA risk too.

Lupus Nephritis: New Decade, New Approaches

Thomas R. Collins  |  November 13, 2020

Experts say progress is being made on a variety of fronts in lupus nephritis. New data, for instance, shows that repeat biopsy beyond that used for diagnosis can help guide treatment and greatly reduce the flare rate. New treatments – including belimumab and the calcineurin inhibitors tacrolimus and voclosporin — have yielded improved response rates in LN…

Can We Predict & Prevent Pregnancy Complications in Patients with Lupus & APS?

Thomas R. Collins  |  November 13, 2020

ACR CONVERGENCE 2020—New evidence, though derived from small numbers, suggest that treatment with the TNF-inhibitor certolizumab could help improve high-risk pregnancy outcomes in women with antiphospholipid syndrome (with or without systemic lupus erythematosus) and lupus anticoagulants, an expert said. In the Phase 2 IMPACT trial, which has already enrolled 27 women and is continuing to…

Lupus Immunology Trends Provide Insights for Rheumatologists

Vanessa Caceres  |  November 12, 2020

ACR CONVERGENCE 2020—With an understanding of the key causes that are behind immune abnormalities in systemic lupus erythematosus (SLE), rheumatologists gain insights into this disease. During the ACR Convergence session Immunology Update—The Decade in Review: 10 Steps to SLE, Chandra Mohan, MD, PhD, Hugh Roy and Lillie Cranz Cullen Endowed Professor, University of Houston, provided…

Newer Targets Pave the Way for Future Lupus Therapies

Vanessa Caceres  |  November 12, 2020

ACR CONVERGENCE 2020—Although rheumatologists have struggled with a lack of new therapies for systemic lupus erythematosus (SLE), recent positive trial results have brought renewed hope for more treatments. That was the theme of the ACR Convergence 2020 session, State of the Art: Lupus—The Future Is Now, led by Peggy Crow, MD, the Benjamin M. Cohen…

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