The Lupus Initiative (TLI) of the American College of Rheumatology (ACR) continues its work to reduce the health disparities for people with lupus through multiple, national-level, grant-funded projects, targeting primary care physicians with lupus education to increase appropriate rheumatology referrals and—when necessary, appropriate and effective—distance-managed care. Since 2009, the ACR has received funding through the…
Air Pollution: Is There an Association with Rheumatic Disease?
Interactions between an individual’s genetic background and their exposure to environmental factors are thought to result in a cascade of immune reactions, ultimately leading to the development of autoimmune diseases such as rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), systemic lupus erythematosus (SLE) and juvenile dermatomyositis.1,2 For example, an environmental factor that conclusively affects susceptibility…
Gene Expression Markers in T Cells Help Identify SLE Patient Subtypes
Researchers used T cell transcriptome analysis in a small-scale study, identifying gene expression of specific patient subtypes and finding that expression alteration of T cells may correlate with severity of SLE rather than its presentation…
SLE—It’s in the Genes
In a large-scale genome-wide association study, researchers mapped 10 new SLE-associated loci and found aberrantly regulated gene expression networks may be behind SLE development…
NIH Director Addresses Gathering of Experts on Autoimmune Diseases
NIH Director Francis Collins, MD, PhD, is working to improve funding for research into new treatments for lupus and RA through the Accelerating Medicines Partnership, a coalition of private and public partners identifying and validating promising biological targets for therapeutics…
Ro60 Autoantigen Regulates Inflammatory Gene Expression
New research links the RNA binding protein Ro60 with SLE pathogenesis and disease-causing inflammation…
The Lupus Initiative Receives 5-Year CDC Grant
The Centers for Disease Control and Prevention (CDC) has awarded the American College of Rheumatology’s (ACR) The Lupus Initiative (TLI) with a five-year grant to support the development of a national, grassroots program targeting primary care providers, persons with undiagnosed Lupus and rheumatology health care providers. The program will have three components: Immediate dissemination of…
FOCIS 2015: Research Increases Understanding of Lupus, RA
The field of rheumatology took center stage when a handful of speakers discussed trends and research during a disease-oriented session of the 2015 Federation of Clinical Immunity Societies (FOCIS 2015) conference held in San Diego in June. Neutrophils in SLE Mariana Kaplan, MD, chief of Systemic Autoimmunity Branch at the National Institute of Arthritis and…
Racial Disparities Result in Unprecedented Differences in Outcomes for SLE Patients
The differences between Caucasian and minority patients with lupus are striking: In almost all aspects of the disease, black, Hispanic and many Asian lupus patients do poorly compared with their white counterparts. Although racial disparities in outcomes in the practice of medicine are widespread, the scope and degree of the differences in lupus is, with…
Selena Gomez Says Suffered from Lupus, Underwent Chemotherapy
(Reuters)—Pop singer and actress Selena Gomez has revealed in an interview that she was diagnosed with the autoimmune disease lupus, which led to her canceling the end of her tour in 2013, but that the disease is now in remission. “I was diagnosed with lupus, and I’ve been through chemotherapy,” Gomez, 23, told Billboard magazine….
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