In a Phase 2 study, researchers found that rontalizumab was a more effective treatment in patients with systemic lupus erythematosus who had an interferon signature metric score lower than 1.
Study Reveals Role of IL-17–Secreting CD4+ T Cells in Lupus
Patients with systemic lupus erythematosus (SLE) are characterized by high-titer, highly specific, isotype-switched antibodies against DNA and RNA. Patients have both CD4+ T helper (Th) cell- dependent as well as Th cell-independent autoantibody production. Two mouse models of lupus demonstrate T-cell–independent autoantibody production: the pristane model of lupus, as well as in the MRL/lpr mouse…
Naive B Cells Activate & Expand During Lupus Flares
New research published in May indicates a possible connection between B cells and the occurrence of systemic lupus erythematosus symptoms.
Plaquenil: From Malaria Treatment to Managing Lupus, RA
In 1984, I wrote my first prescription for the antimalarial drug, hydroxychloroquine (Plaquenil), for a 28-year-old woman with SLE. She was considerably overweight, with inflammatory arthritis and a photosensitive rash, and I worried that oral corticosteroids would tip her over into diabetes. I presented the case to my attending, Steven Malawista, MD, at the Yale…
2014 ACR/ARHP Annual Meeting: Super Proteins Eyed in Therapies for Rheumatic Diseases
Immunoglobulin superfamily of proteins, CTLA-4 and PD-1, may generate treatments for RA, SLE
Atherosclerosis Insights May Shed Light on Lupus
New research compares pathogenic immune response in SLE with immune response that contributes to atherosclerotic plaque
Seizures in Lupus
Case report highlights important twist to differential diagnosis of neuropsychiatric lupus
Case Report: Contagious Rash in Active Systemic Lupus Erythematosus
Consider a diagnosis of crusted scabies in immunosuppressed patients who develop a persistent, pruritic rash
2014 ACR/ARHP Annual Meeting: Lupus Nephritis
Multi-targeted, aggressive drug therapies needed for complete response, remission of this lupus complication
Proptosis in Systemic Lupus Erythematosus
Diagnosing orbital disease in patients with rheumatic conditions
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