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Search results for: Biologics

Novartis Biosimilar Takes Aim at Amgen’s Enbrel

Michael Shields & Ben Hirschler  |  October 2, 2015

ZURICH (Reuters)—The U.S. Food and Drug Administration has accepted Novartis unit Sandoz’s regulatory submission for approval of a biosimilar copy of Amgen’s blockbuster anti-TNF drug Enbrel, the Swiss drugmaker said on Friday. Enbrel, or etanercept as the drug is known generically, is a big prize since it was the world’s fifth-biggest selling medicine in 2014…

Filed under:Biologics/DMARDsDrug Updates Tagged with:Amgenanti-TNF agentetanerceptFDAFood and Drug AdministrationNovartis

Relapse Rates High in IBD Patients who Stop Treatment

Megan Brooks  |  September 28, 2015

NEW YORK (Reuters Health)—Inflammatory bowel disease (IBD) patients who achieve remission on treatment may want to go off their IBD medications. But half or more of those who do will have a relapse, according to comprehensive analysis of relevant research. “Based on the studies with extended periods of follow up, relapse rates after cessation appear…

Filed under:ConditionsOther Rheumatic Conditions Tagged with:anti-TNF agentCrohn's diseaseinflammatory bowel diseaseMedication Management

Depression & Anxiety Linked to Poor Rheumatoid Arthritis Outcomes

Rob Goodier  |  September 18, 2015

NEW YORK (Reuters Health)—Rheumatoid arthritis patients with depression and anxiety symptoms may have worse outcomes and poorer response to prednisolone, a secondary analysis of the CARDERA trial has found. “The strength of association between depression/anxiety and disease activity outcomes and treatment response warrants routine screening,” the study’s lead author Faith Matcham at King’s College London…

Filed under:ConditionsRheumatoid Arthritis Tagged with:anxiety disordersDepressionoutcomeRheumatoid Arthritis (RA)

New Labeling for Infused Golimumab; Phase 3 Trial for Romosozumab Promising

Michele B. Kaufman, PharmD, BCGP  |  September 16, 2015

The FDA has approved new labeling for infused golimumab to include measures of mental and physical health. Plus romosozumab meets primary endpoints in postmenopausal women with osteoporosis during a Phase 3 trial…

Filed under:Biologics/DMARDsConditionsDrug UpdatesOsteoarthritis and Bone Disorders Tagged with:combination therapyFDAFood and Drug AdministrationGolimumabInjectionMental HealthMethotrexateOsteoporosispostmenopauseromosozumab

Rheumatologists on the Move, September 2015

Ann-Marie Lindstrom  |  September 15, 2015

Teresa Fama: Rheumatologist to Chair Public Advisory Council Teresa Fama, MD, is the new chair of the New England Comparative Effectiveness Public Advisory Council (CEPAC). A rheumatologist who practices in Berlin, Vt., Dr. Fama has previous experience in public policy, specifically health policy. Before she began her second career as a physician, Dr. Fama was…

Filed under:Career DevelopmentProfessional TopicsProfiles Tagged with:appointmentsAwardsCareerrheumatologist

Preparing Immunocompromised Patients for Risks of Traveling Abroad

Susan Bernstein  |  September 15, 2015

Summer is a season for travel, so if your immunocompromised patients plan to journey to regions where there are outbreaks of infections, such as chikungunya, tuberculosis, typhoid, yellow fever or other diseases, communication and preparation may prevent serious health events. “The world teems with disease-causing organisms, and almost every infection is more serious in the…

Filed under:Conditions Tagged with:ClinicalDiseaseoutbreakspatient carerheumatologistsrisk

Engaging Patients to Enhance Rheumatology Research

Susan Bernstein  |  September 15, 2015

It takes a great deal of time and money to produce clinical practice guidelines for rheumatic diseases. No matter how well a treatment inhibits inflammatory cytokines, it won’t lower disease activity without one essential factor: patient compliance. “You can’t propose a treatment algorithm in your research that no patient would actually use,” says Veena Ranganath,…

Filed under:EthicsPractice SupportProfessional Topics Tagged with:Outcomespatient carerheumatologists

Guselkumab Studied to Treat RA, Plaque Psoriasis

Michele B. Kaufman, PharmD, BCGP  |  September 15, 2015

Guselkumab Studied to Treat RA & Plaque Psoriasis Guselkumab (GUS) is a subcutaneously administered monoclonal antibody that targets interleukin (IL) 23.1 It is being investigated in a Phase 2 study to treat rheumatoid arthritis (RA) and moderate to severe plaque psoriasis (PsA). On June 11, 2015, at the 2015 meeting of the European League Against…

Filed under:Biologics/DMARDsConditionsDrug UpdatesRheumatoid Arthritis Tagged with:Biosimilarsclinical trialsDrugsguselkumaboutcomeplaque psoriasisRheumatoid arthritisrheumatologySafety

EULAR 2015: Cardiovascular Concerns, Infertility in RA

Thomas R. Collins  |  September 15, 2015

ROME, Italy—In what researchers say is the first study evaluating cardiac magnetic resonance (CMR) findings in early rheumatoid arthritis (ERA) patients, cardiovascular abnormalities were significantly worse in patients with ERA than in matched, healthy controls. The study results were presented at EULAR 2015, the annual congress of the European League Against Rheumatism (EULAR). Cardiovascular Concerns…

Filed under:ConditionsMeeting ReportsRheumatoid Arthritis Tagged with:cardiovascularinfertilityoutcomepatient careRARheumatoid arthritis

Lupus Nephritis Therapies Compared, Plus Naming Guidance for Biosimilars

Michele B. Kaufman, PharmD, BCGP  |  September 9, 2015

Comparing tacrolimus, mycophenolate mofetil and cyclophosphamide, tacrolimus was the most efficacious. Also, biosimilars may soon be easier to differentiate…

Filed under:Biologics/DMARDsDrug Updates Tagged with:Biologics & BiosimilarscyclophosphamideFDAFood and Drug AdministrationLabeling ChangesLupus nephritismycophenolate mofetiltacrolimus

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