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ABX464 in Phase 2a Trials for RA

Michele B. Kaufman, PharmD, BCGP  |  June 29, 2020

Research is examining the safety and tolerability of two different doses of ABX464 in patients with moderate to severe active RA…

Filed under:Drug Updates Tagged with:ABX464Rheumatoid Arthritis (RA)

Research Beyond COVID-19: Collateral Damage

Nancy A. Delnay, MSN, CNP; Charmayne M. Dunlop-Thomas, MS, MPH; Rebecca J. Cleveland, PhD; Cynthia S. Crowson, PhD; Joshua Stefanik, MSPT, PhD; Jungwha Lee, PhD, MPH; Kendra Young, MSPH, PhD; & Dina L. Jones, PT, PhD  |  June 23, 2020

COVID-19 has generated an outpouring of fast-paced, late-breaking new developments. The majority of countries (188) around the world have reported cases of COVID-19.1 As of April 1, 2020, the Centers for Disease Control and Prevention had reported cases in every U.S. jurisdiction (50 states, District of Columbia, Puerto Rico, Guam, the Northern Mariana Islands and…

Filed under:Education & TrainingResearch Rheum Tagged with:COVID-19

Zoledronate After Denosumab Does Not Fully Prevent Bone Loss

Marilynn Larkin  |  June 23, 2020

NEW YORK (Reuters Health)—In postmenopausal women and men treated for at least two years with denosumab, a single infusion of zoledronate given after denosumab discontinuation does not completely prevent bone turnover and loss, researchers say. Given the findings, “bone mineral density (BMD) should probably be higher than the current target for discontinuation of bisphosphonate treatment…

Filed under:ConditionsOsteoarthritis and Bone Disorders Tagged with:bone lossbone mineral density (BMD)denosumabOsteoporosisosteoporosis treatmentszoledronate

Tocilizumab Fails to Help COVID-19 Patients in Italian Study

Emilio Parodi & Carl O'Donnell  |  June 23, 2020

(Reuters)—Roche’s rheumatoid arthritis drug Actemra (tocilizumab) failed to help patients with early-stage COVID-19 pneumonia in an Italian study, the latest instance in which an anti-inflammatory drug has fallen through in a coronavirus trial. Despite the setback, the Swiss drugmaker said that it is pressing ahead with testing tocilizumab in another trial against COVID-19, the disease…

Filed under:Drug Updates Tagged with:coronavirusCOVID-19tocilizumab

Respiratory Failure More Common in COVID-19 Patients with Rheumatic Disease

Marilynn Larkin  |  June 23, 2020

NEW YORK (Reuters Health)—COVID-19-infected patients with rheumatic disease were more likely to experience respiratory failure than those without rheumatic disease, according to a retrospective study in China. “Immune dysregulation underlying rheumatic diseases may affect the disease manifestation of COVID-19,” Dr. Jixin Zhong of Huazhong University of Science and Technology, Wuhan, tells Reuters Health by email….

Filed under:Uncategorized Tagged with:coronavirusCOVID-19respiratoryRheumatic Disease

Some Rheumatic Diseases Tied to Higher Risk of Severe COVID-19

Megan Brooks  |  June 23, 2020

NEW YORK (Reuters Health)—Patients with some inflammatory rheumatic conditions are at higher risk for hospital-diagnosed COVID-19 infection compared with the general population, but it depends on the condition and therapy used to treat it, according to a study from Spain. It’s now clear that older patients and those with some common diseases are at increased…

Filed under:Conditions Tagged with:coronavirusCOVID-19Rheumatic Disease

COVID-19: Most Individuals with Rheumatic Disease Recover

Lara C. Pullen, PhD  |  June 19, 2020

An analysis of data from the COVID-19 Global Rheumatology Alliance registry shows that use of disease-modifying antirheumatic drugs or non-steroidal anti-inflammatory drugs did not increase the risk of hospitalization for COVID-19 patients with rheumatic disease, but steroid use did.

Filed under:Conditions Tagged with:COVID-19COVID-19 Global Rheumatology AllianceDr. Milena GianfrancescoDr. Philip Robinsonpatient outcomes

Dr. Kawasaki

Tomisaku Kawasaki, Pediatrician Who Discovered Disease That Bears His Name, Dies at 95

Renée Bacher  |  June 18, 2020

Japanese pediatrician Tomisaku Kawasaki, MD, who identified an inflammatory syndrome that affects children, died on June 5 in Tokyo. He was 95. Tenacity & Attention to Detail Born Feb. 7, 1925, in Tokyo, Dr. Kawasaki graduated from medical school at what is now Chiba University in Chiba, Japan, in 1948 and worked as staff pediatrician…

Filed under:Professional TopicsProfiles Tagged with:KawasakiKawasaki diseaseTomisaku Kawasaki

More Evidence Links Pediatric Inflammatory Multisystem Syndrome to SARS-CoV-2

Will Boggs, MD  |  June 18, 2020

NEW YORK (Reuters Health)—Two new reports in JAMA strengthen the link between SARS-CoV-2 infection and pediatric inflammatory multisystem syndrome (PIMS). Pediatricians from several communities have reported children who developed fever and multisystem inflammation during the COVID-19 pandemic. Some children were critically ill and some had characteristics similar to Kawasaki disease or Kawasaki disease shock syndrome….

Filed under:ConditionsPediatric Conditions Tagged with:ChildrenCOVID-19Kawasaki diseasePediatricpediatric inflammatory multisystem syndrome (PIMS)

After Hip Fracture, Earlier Osteoporosis Drug Initiation Tied to Lower Subsequent Fracture Risk

Lisa Rapaport  |  June 15, 2020

(Reuters Health)—Patients hospitalized for a hip fracture are less likely to experience a subsequent fracture-related hospitalization if they start anti-osteoporosis medication sooner, a Taiwanese study suggests.1 Researchers examined data on 77,930 patients aged 50 years and older hospitalized for hip fractures, including 9,986 people prescribed anti-osteoporosis medications within one year of the index fracture. Compared…

Filed under:ConditionsOsteoarthritis and Bone Disorders Tagged with:drug treatmentFracturesOsteoporosisosteoporosis treatments

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