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Articles tagged with "immune checkpoint inhibitor (ICI)"

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Rheumatic Complications from Immune Checkpoint Inhibitors

Nilasha Ghosh, MD, MS, & Anne R. Bass, MD  |  December 16, 2021

Immune checkpoint inhibitors (ICIs), such as anti-programmed cell-death 1/programmed death-ligand 1 (anti-PD-1/PD-L1) or anti-CTL-associated protein (anti-CTLA-4), have dramatically changed the treatment of advanced cancers over the past decade. ICIs block T cell inhibition, thus increasing the anti-tumor immune response. ICIs are used not only for metastatic cancer, but also as adjuvant treatment for some stage…

Reassuring Data on Immune Checkpoint Inhibitors in Autoimmune Disease

Reuters Staff  |  February 22, 2021

NEW YORK (Reuters Health)—Patients with preexisting autoimmune disease (AIDs) are not at increased risk for immune-related adverse events from immune checkpoint inhibitor (ICI) therapy, although these adverse events may be more likely in patients with inflammatory bowel disease (IBD), new research indicates. “Therefore, we encourage physicians not to withhold ICI in most common AIDs. However,…

ACR Convergence graphic

Check It Out: Understanding Immune-Related Adverse Events from Immune Checkpoint Inhibitors

Jason Liebowitz, MD, FACR  |  December 4, 2020

Immune checkpoint inhibitors effectively treat malignancy in ways that were not possible just a few years ago, but immune-related adverse events are a potential side effect.

Ultrasound Provides Insights into Immune Checkpoint Inhibitor‐Induced Inflammatory Arthritis

Elizabeth Hofheinz, MPH, MEd  |  October 12, 2020

Ultrasound may provide unique insights into the effects of immune checkpoint inhibitors on the human body beyond the immune system. Research suggests synovitis and inflammatory tendon involvement are commonly seen in patients with immune checkpoint inhibitor-induced inflammatory arthritis.

Insights into Immune Checkpoint Inhibitor-Induced Inflammatory Arthritis

Lara C. Pullen, PhD  |  July 29, 2020

Recent research found inflammatory arthritis caused by immune checkpoint inhibitors (ICIs) may become a long-term disease, requiring rheumatology care and immunomodulatory treatment. Some patients experience active inflammatory arthritis years after ICI cessation…

Nivolumab-Induced Arthritis

Catherine Strahle, DO, Nathalie E. Chalhoub, MD, & Avis Ware, MD  |  October 18, 2018

Immune checkpoint inhibitors (ICIs) are increasingly used to treat a variety of malignancies, leading to better cancer treatment outcomes and patient survival. However, the emergence of autoimmunity has been a major adverse event resulting from ICI use. Below, we describe a patient who experienced a flare of preexisting psoriasis and new-onset severe psoriatic arthritis after…

Study Assesses Immune Checkpoint Inhibitors Safety in Rheumatic Disease

Kurt Ullman  |  May 18, 2018

Since they were first introduced in 2011, immune checkpoint inhibitors (ICIs) have become an important treatment for an expanding list of advanced cancers. Some concerns have been raised around the mechanism of action of these immunotherapy agents, making their use in rheumatic diseases (RD) problematical. An article in the March 2018 issue of Arthritis &…

Complex Treatment: Cancer, Immunotherapy & Rheumatic Disease

Richard Quinn  |  May 6, 2017

Some cancer patients taking immune checkpoint inhibitors experience immune-related adverse events. Laura C. Cappelli, MD, MHS, says rheumatologists are natural partners with oncologists to treat this patient population…

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