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Articles tagged with "osteoarthritis (OA)"

Hyaluronidase 2 May Play an Important Role in OA Progression

Lara C. Pullen, PhD  |  September 5, 2017

A new study in mice found that Hyal2 deficiency may play a role in the turnover of cartilage hyaluronan, resulting in an accumulation of hyaluronan and, eventually, the development of osteoarthritis. Researchers suspect these results indicate an imbalance in the metabolism of hyaluronan…

Calcium Crystal Deposition in Rheumatic Diseases: Mechanisms & Evaluation of Calcium Crystal Deposits Explored

Thomas R. Collins  |  August 15, 2017

MADRID—Calcification in osteoarthritis (OA) involves a series of pathways and interactions that feed off each other in a process that bears some resemblance to the transformation of cartilage to bone that takes place in the embryonic stage of human development, a researcher said here at the 2017 Annual European Congress on Rheumatology (EULAR). “My hypothesis…

Genetic Analysis Provides Insights into How Human Growth Is Linked to OA

Lara C. Pullen, PhD  |  July 31, 2017

Research has shed light on the genetic mutations that link GDF5 with arthritis and height. An ancient regulatory variant in GROW1 has been repeatedly selected in humans in northern environments, explaining the high frequency of a GDF5 haplotype that increases arthritis susceptibility…

Adenosine Treatment Promotes Cartilage Homeostasis

Lara C. Pullen, PhD  |  June 26, 2017

A recent study in mice examined the role of adenosine A2A receptors in joint health. Researchers specifically found that as extracellular levels of adenosine fall, individuals may become at risk for osteoarthritis…

‘Booster Sessions’ May Help Older Adults Stick with Arthritis Exercises

Lorraine L. Janeczko  |  February 7, 2017

NEW YORK (Reuters Health)—”Booster sessions” with a physiotherapist help older adults with osteoarthritis keep doing their exercises, a new systematic review and meta-analysis suggests. “There is strong evidence for the benefits of exercise for people with osteoarthritis or chronic low back pain. However, multiple studies have shown adherence to exercise declines over time, and the…

Low Levels of Vitamin D3 May Increase OA Pain

Lara C. Pullen, PhD  |  December 20, 2016

In a study of patients with knee osteoarthritis (OA), researchers found that the cytokine IL-17A may play a role in the pain associated with the disease. Specifically, decreased serum levels of vitamin D3 may contribute to OA pain via the regulation of immune responses…

New Insights into the Structure of Collagen Fibril

Lara C. Pullen, PhD  |  December 5, 2016

A study of knee and hip articular cartilage found that thick fibers were bundles of thin fibrils—like a multi-thread rope in which each thread corresponds to a prototypic sub-fibril. The organization of the fibers also differed between the cartilages of distinct tissues, which may explain how a breakdown in the fiber pattern contributes to pathology…

Many Patients Discontinue Tofacitinib by Year 1; Fasinumab Promising for Pain

Michele B. Kaufman, PharmD, BCGP  |  November 2, 2016

A recent analysis found that about 10% of RA patients taking tofacitinib do not follow recommended guidelines and more than half stop treatment by one year…

Healthy Clones: Dolly the Sheep’s Heirs Reach Ripe Old Age

Ben Hirschler  |  July 26, 2016

LONDON (Reuters)—The heirs of Dolly the sheep are enjoying a healthy old age, proving cloned animals can live normal lives and offering reassurance to scientists hoping to use cloned cells in medicine. Dolly, cloning’s poster child, was born in Scotland in 1996. She died prematurely in 2003, at age 6, after developing osteoarthritis and a…

Inflammation May Sensitize Patients with Osteoarthritis to Pain

Lara C. Pullen, PhD  |  May 30, 2016

A recent editorial in Arthritis & Rheumatology explored the role of sensitization, not nociception, as a key mechanism of pain for patients with knee OA, as well as inflammation’s role in pain perception. Recent research of synovitis and joint effusion supports the idea that early prevention or treatment of sensitization may be paramount to reducing long-term pain in patients with knee OA…

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