Recent clinical trials have evaluated the efficacy of GSK3196165, a monoclonal antibody, and fasinumab, a nerve growth factor antibody, in treating patients with osteoarthritis and pain…
Foot Orthoses vs. Rocker-Sole Footwear: Which Treatment Is More Effective for Reducing Pain in First MPT Joint OA?
Foot osteoarthritis (OA) of the first metatarsophalangeal (MTP) joint is thought to have biomechanical factors, but its treatments have not been comprehensively tested in clinical trials. In the first study to explore the efficacy of mechanical interventions, researchers compared the effectiveness of foot orthoses and rocker-sole footwear in reducing pain. Both interventions were effective, but the foot orthoses group wore the intervention for significantly more hours than the footwear group…
Researchers Work to Untangle the Relationship Between Blood Lipids, Bone Health & Diet
A recent editorial examined research findings on how low levels of high-density lipoprotein (HDL) in the blood affect bone health, resulting in cartilage dysfunction and the development of osteoarthritis (OA). Authors note that a high-fat diet in mice with HDL deficiency resulted in OA development; thus, they conclude that in patients with metabolic syndrome, HDL may have a causative relationship to OA…
Combo Drug for Arthritis & Hypertension Meets Goal in Phase 3 Study
(Reuters)—Kitov Pharmaceuticals Holdings Ltd. said on Tuesday its lead drug, KIT-302, met the main goal of a late-stage study, reducing pain without increasing the risk of heart diseases in patients with osteoarthritis. Israel-based Kitov says its drug does not need to be labeled with health warnings, but will instead say it reduces the risk of…
Exercise Helps Manage Hip Osteoarthritis Pain
(Reuters Health)—Water- or land-based exercise should provide some short-term benefit in pain management for hip osteoarthritis, though there are few well-designed trials testing it, according to a new review. “It is nice to finally have some hip-specific data, as hip and knee osteoarthritis are often grouped together, and it’s almost certain that there are differences…
Vitamin C Derivative Promising Option for OA
New research in mice has found that treatment with a vitamin C derivative can effectively suppress the generation of mitochondrial superoxide, which plays a role in cartilage degeneration and the progression of osteoarthritis…
Envision Arthritis Pathology
MRI advances in RA and OA
Osteoarthritis Quo Vadis
Our knowledge of OA has progressed far—does a cure lie ahead?
Take the Measure of Osteoarthritis
The WOMAC index standardized OA status measurement, as described by its creator
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