ACR CONVERGENCE 2021—Using pooled data from the TULIP-1 and TULIP-2 clinical trials, researchers set out to identify whether more patients with systemic lupus erythematosus (SLE) being treated with anifrolumab achieved a low disease activity state than patients with SLE who received placebo.1-3 An analysis of the data was presented at ACR Convergence 2021 by Eric…
A special article in the December issue of Arthritis & Rheumatology summarizes the current understanding of the cardiac toxicity of HCQ and CQ.
Predicting a patient’s disease course is difficult, especially in SLE. A recent study examined the link between a patient’s 2019 EULAR/ACR SLE Classification Criteria score at diagnosis to subsequent disease severity, finding a score of 20 or more may predict a more severe disease course.
In the 2021 Edmund L. Dubois, MD, Memorial Lectureship, Aimee Hersh, MD, discussed her work on defining research priorities in pediatric lupus.
PRSYM—At the 2021 Pediatric Rheumatology Symposium (PRSYM), a session on lupus provided a robust discussion of recent advances in lupus treatments and genetic discoveries in pediatric rheumatology. Lupus Nephritis The first speaker was Shaun Jackson, MD, PhD, a pediatric nephrologist and rheumatologist and associate professor at Seattle Children’s. His presentation focused on state-of-the-art treatments in…
Patients with the rare DNASE1L3 biallelic null mutation present with childhood-onset disease that resembles lupus. This observation prompted research into how abnormalities in the enzyme DNASE1L3 are associated with lupus, with researchers finding autoantibody-mediated impairment of DNASE1L3 activity may be a common non-genetic mechanism leads to anti-dsDNA autoreactivity in SLE.
A recent study demonstrated that exposure to type I interferon contributes to the pathogenesis of SLE via the metabolic rewiring of CD8+ T cells, which promotes cell death.
Platelets may be a key source of mitochondrial antigens in systemic lupus erythematosus, according to a recent study.
Can machine learning aid clinicians in diagnosing systemic lupus erythematosus? Adamichou et al. designed an algorithm that uses classical features of lupus to simulate medical reasoning and identify lupus early in the disease process. They were able to validate the algorithm, which demonstrated high sensitivity, specificity and accuracy.
In September 2020, the ACR received a $7 million grant for a four-pronged SLE approach that seeks to address gaps and inequities in SLE through physician education, medical school outreach, pediatric support and disease management.