Platelets may be a key source of mitochondrial antigens in systemic lupus erythematosus, according to a recent study.
Lupus or Not? Machine Learning May Help Diagnose Lupus Early
Can machine learning aid clinicians in diagnosing systemic lupus erythematosus? Adamichou et al. designed an algorithm that uses classical features of lupus to simulate medical reasoning and identify lupus early in the disease process. They were able to validate the algorithm, which demonstrated high sensitivity, specificity and accuracy.
CDC-Funded RISE Project Aims to Improve Systemic Lupus Erythematosus Patient Outcomes
In September 2020, the ACR received a $7 million grant for a four-pronged SLE approach that seeks to address gaps and inequities in SLE through physician education, medical school outreach, pediatric support and disease management.
Familial Patterns in Childhood- & Adult-Onset SLE
A study examining familial patterns of systemic lupus erythematosus (SLE) found a greater decline in SLE recurrence rate by generation in childhood- than in adult-onset SLE, suggesting adult-onset SLE may be characterized by environmental risk factors.
The Environment Within: A Possible Link Identified Between Plasma Microbial Translocation & Autoantibody Development in 1st Degree Relatives of SLE Patients
Plasma microbial translocation, the composition of the microbiome and environmental factors may influence the development of autoantibodies in patients with systemic lupus erythematosus (SLE), according to a study comparing SLE patients with their first-degree relatives and unrelated, healthy controls.
Monthly Belimumab Infusions Preserve Kidney Function in Some Lupus Patients
(Reuters Health)—Intravenous belimumab combined with standard lupus therapy can help preserve kidney function in patients with active lupus nephritis and cut the odds of death or a renal-related event by half, a phase 3 multinational study has concluded.1 After two years of therapy, 43% of 224 volunteers getting the drug monthly showed a renal response…
How to Empower Lupus Patients Through Social Media & Online Resources
Social media connections, such as LupusChat and online resources from the ACR’s Lupus Initiative, are providing safe spaces and support for lupus patients during the COVID-19 pandemic…
Unified Signature of SLE May Advance Clinical Diagnosis & Biomarker Development
Researchers have identified 93 genes that may play a role in systemic lupus erythematosus (SLE), including 47 genes not previously associated with SLE. Theresulting transcriptome has revealed underappreciated genes and pathways associated with the pathogenesis of SLE…
Lupus Nephritis: Understanding the Paradigm for Treatment
ACR BEYOND LIVE—Among patients with systemic lupus erythematosus (SLE), lupus nephritis remains one of the leading causes of mortality, and patients with both SLE and end-stage renal disease demonstrate standardized mortality ratios higher than 60 times that of patients with SLE who have normal kidney function.1 Although the ACR Guidelines for Screening, Treatment, and Management…
Upper Limb Exercise May Improve Quality of Life for Lupus Patients
A recent study found SLE patients may improve their daily physical function, pain and overall quality of life by adding upper limb exercises to stable treatment regimens and routine care…
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