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Search results for: girnita

Case Report: Pulmonary Sarcoid-Like Reaction in Patient Treated with Etanercept

Luis Lora Garcia, MD, Sneha Centala, MD, MS, Gitanjali Lobo, MD, Shahla Mallick, MD, & Diana Girnita, MD, PhD  |  April 15, 2022

Sarcoidosis is a multisystem disease characterized by noncaseating granulomas in affected tissues, mostly involving the lungs and lymph nodes.1,2 The etiology of sarcoidosis remains unknown but is thought to be due to an inflammatory response to an antigen exposure in genetically predisposed individuals.1 Tumor necrosis factor-α (TNF‑α), a pro-inflammatory cytokine, plays an essential role in…

Filed under:ConditionsOther Rheumatic Conditions Tagged with:case reportetanerceptFellowspulmonary sarcoidosisSarcoidosis

Case Report: A Patient Develops Scleroderma Renal Crisis

Adria Madera-Acosta, MD, Teresa Sosenko, MD, & Diana Girnita, MD, PhD  |  October 18, 2019

Scleroderma renal crisis (SRC) is a life-threatening complication of systemic sclerosis. SRC occurs in 2–15% of patients with diffuse sclerosis and usually within the first five years from the time of diagnosis. Risk factors for SRC include, but are not limited to, early diagnosis, corticosteroid or cyclosporine use, and the presence of anti-RNA polymerase III…

Filed under:ConditionsSystemic Sclerosis Tagged with:case reportdiffuse systemic sclerosisScleroderma Renal Crisis

Figure 1. A nasal biopsy shows intimal infiltration of the small blood vessels (black arrow).

Case Illustrates the Difficulty Diagnosing Granulomatosis with Polyangiitis

Diana Girnita, MD, PhD, & Vishnuteja Devalla, MD  |  June 21, 2018

Granulomatosis with polyangiitis (GPA) was first described in the British Medical Journal in 1897 by Scottish otolaryngologist Peter McBride.1 GPA is a relatively rare, systemic necrotizing vasculitis that can make diagnosis challenging. The incidence has been estimated anywhere between two and 12 cases per million.2 GPA mainly affects adults between the ages of 45 and…

Filed under:Vasculitis Tagged with:ANCAanti-neutrophil cytoplasmic antibodies (ANCA)BiomarkersbiopsyGPAgranulomatosis with polyangiitis

Case Review: Lupus Patient with Acute Disseminating Encephalomyelitis

Teresa Sosenko, MD, Anca Musetescu, MD, PhD, Neha Gandhi, MD, Scott Friedstrom, MD, & Diana Girnita, MD, PhD  |  January 19, 2018

Systemic lupus erythematosus (SLE) is an autoimmune-mediated rheumatic disease characterized by multisystem involvement that can cause significant morbidity and mortality. Acute disseminated encephalomyelitis (ADEM) is a rare, fulminant, autoimmune-mediated, demyelinating disease involving the white matter of the central nervous system (CNS), and is considered a manifestation of neuropsychiatric lupus. Few reported cases involve SLE and…

Filed under:ConditionsMeeting ReportsSystemic Lupus Erythematosus Tagged with:ACR/ARHP Annual MeetingbrainClinicalDiagnosisdruglab testLupusmagnetic resonance imagingMRIoutcomepatient careprednisonepsychological disorderrheumatologistrheumatologySystemic lupus erythematosusTreatmentX-ray

Pharmacokinetics May Be Factor in Success of Pegloticase Therapy for Gout

From the College  |  October 11, 2016

We read the case report by Dr. Diana Girnita and colleagues (“Severe Refractory Gout: What options are left when pegloticase fails?” The Rheumatologist, August 2016) with interest. A case is reported of a subject with 20 years of chronic refractory gout who failed to respond to pegloticase therapy, and the potential roles of anti-drug antibodies or…

Filed under:ConditionsGout and Crystalline ArthritisOther Rheumatic Conditions Tagged with:failureGoutpegloticasepharmacokineticssuccessThe RheumatologisttherapyTreatment

Treatment Options for Severe Refractory Gout When Pegloticase Fails

Diana M. Girnita, MD, PhD, Cody Lee, MD, & Christine Chhakchhuak, MD  |  August 12, 2016

Pegloticase is a new alternative therapy for patients with severe, refractory gout unresponsive to other urate-lowering agents. The goal of this therapy is to reduce disease burden, tophi size and frequency of flares and to improve quality of life when other treatments have failed. Persistent lowering of plasma uric acid (PUA) to less than 6…

Filed under:ConditionsGout and Crystalline ArthritisResearch Rheum Tagged with:ClinicalGoutoutcomepegloticaseResearchrheumatologistrheumatologyTreatment

Rheumatoid Arthritis & Autoimmune Glomerulonephritis

Rheumatoid Arthritis & Autoimmune Glomerulonephritis

Diana M. Girnita, MD, PhD, Shahzad Safdar, MD, & Avis Ware, MD  |  June 13, 2016

Rheumatoid arthritis (RA) is rarely associated with renal manifestations, but secondary amyloidosis due to chronic inflammation is reported to be the etiology of renal dysfunction in many cases of RA.1,2 The discovery of biologic therapy, with TNF-alpha inhibitors in particular, made a huge difference in the disease course and prognosis of RA patients. However, TNF-alpha…

Filed under:ConditionsRheumatoid Arthritis Tagged with:Autoimmunecase reportClinicalDiagnosisGlomerulonephritisimmune complexpatient careRenalRheumatoid arthritisrheumatologyTNF-Alpha inhibitor

Case Report: Sternoclavicular Erosions in a Patient with Uncontrolled RA

Diana M. Girnita, MD, PhD, Avis Ware, MD, Sangita Kapur, MD, & Christine Chhakchhuak, MD  |  December 17, 2015

Sternoclavicular joint involvement has rarely been reported in the context of active rheumatoid arthritis (RA).1 Traditionally, rheumatologists use serial radiographs of hands and feet to diagnose, monitor for progression or evaluate the response to treatment. The sternoclavicular (SC) joint is not a typical joint assessed for RA. However, the fact that it is a diarthrodial…

Filed under:ConditionsRheumatoid Arthritis Tagged with:ClinicalDiagnosisoutcomepatient careRARheumatoid arthritisSCsternoclavicular jointTreatment

The ACR Board of Directors, Foundation Board of Directors, & ARHP Executive Committee Welcome New Members

From the College  |  February 1, 2015

New members announced at 2014 ACR/ARHP Annual Meeting in Boston

Filed under:From the College Tagged with:ACR/ARHP Annual Meetingmembersrheumatology

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