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You are here: Home / Search for "inhibitor"

Search results for: inhibitor

Check It Out: Understanding Immune-Related Adverse Events from Immune Checkpoint Inhibitors

December 4, 2020 • By Jason Liebowitz, MD

ACR Convergence graphic

Immune checkpoint inhibitors effectively treat malignancy in ways that were not possible just a few years ago, but immune-related adverse events are a potential side effect.... [Read More]

Filed Under: ACR Convergence, Drug Updates, Meeting Reports Tagged With: ACR Convergence 2020, immune checkpoint inhibitor (ICI), Immune checkpoint inhibitors, immunotherapy

Study: DPP4 Inhibitors Yield Promise for Systemic Sclerosis Treatment

November 12, 2020 • By Ruth Jessen Hickman, MD

A recent paper in Arthritis & Rheumatology opens up the possibility of a new research avenue to treat systemic sclerosis: dipeptidyl peptidase 4 (DPP4) inhibitors, a previously approved therapy for type 2 diabetes.1 Work in mouse models and on skin samples from systemic sclerosis patients suggests these drugs pose a promising area of future translational… [Read More]

Filed Under: Conditions, Research Reviews, Systemic Inflammatory Syndromes Tagged With: DPP4 inhibitor, systemic sclerosis (SSc)

Ultrasound Provides Insights into Immune Checkpoint Inhibitor‐Induced Inflammatory Arthritis

October 12, 2020 • By Elizabeth Hofheinz, MPH, MEd

Ultrasound may provide unique insights into the effects of immune checkpoint inhibitors on the human body beyond the immune system. Research suggests synovitis and inflammatory tendon involvement are commonly seen in patients with immune checkpoint inhibitor-induced inflammatory arthritis.... [Read More]

Filed Under: Conditions Tagged With: ACR Open Rheumatology, ICI‐induced inflammatory arthritis, immune checkpoint inhibitor (ICI), Immune checkpoint inhibitors, Inflammatory arthritis, Ultrasound

Janus Kinase vs. TNF Inhibitors: The Context for Venous Thromboembolism Risk with RA Treatments

October 7, 2020 • By Larry Beresford

An observational study found treatment with tofacitinib resulted in only a slightly higher rate of venous thromboembolism than tumor necrosis factor inhibitors in patients with rheumatoid arthritis.... [Read More]

Filed Under: DMARDs & Immunosuppressives, Drug Updates Tagged With: JAK inhibitors, jakinib, Rheumatoid Arthritis (RA), TNF inhibitors, Tofacitinib

Nerve Growth Factor Inhibitor Study Highlights Promise as an OA Pain Treatment

October 1, 2020 • By Ruth Jessen Hickman, MD

A study highlights the potential of fasinumab, an anti-nerve growth factor monoclonal antibody, as a pain treatment for osteoarthritis (OA) patients. Research into the risks and benefits of this therapeutic class for OA are ongoing…... [Read More]

Filed Under: Drug Updates, Osteoarthritis Tagged With: Arthritis & Rheumatology, fasinumab, Knee Osteoarthritis (OA), Nerve growth factor (NGF), osteoarthritis (OA), tanezumab

PCSK9 Inhibitors May Lower Cholesterol in Patients with Statin-Associated Immune-Mediated Necrotizing Myopathy

September 23, 2020 • By Vanessa Caceres

A 2019 study demonstrated the benefit of a newer drug class, PCSK9 inhibitors, to help lower cholesterol in patients with statin-associated immune-mediated necrotizing myopathy…... [Read More]

Filed Under: Drug Updates Tagged With: Arthritis & Rheumatology, cholesterol, immune-mediated necrotizing myopathy, PCSK9 inhibitors, protein convertase subtilisin/kexin type 9 inhibitors, statin-associated myopathy

Insights into Immune Checkpoint Inhibitor-Induced Inflammatory Arthritis

July 29, 2020 • By Lara C. Pullen, PhD

Recent research found inflammatory arthritis caused by immune checkpoint inhibitors (ICIs) may become a long-term disease, requiring rheumatology care and immunomodulatory treatment. Some patients experience active inflammatory arthritis years after ICI cessation…... [Read More]

Filed Under: Conditions Tagged With: immune checkpoint inhibitor (ICI), Immune checkpoint inhibitors, Inflammatory arthritis

Interleukin 17 Inhibitors Promising in Ankylosing Spondylitis Patients

July 10, 2020 • By Michele B. Kaufman, PharmD, BCGP

In patients with active ankylosing spondylitis, IL-17 inhibitors have produced favorable responses, according to recent research…... [Read More]

Filed Under: DMARDs & Immunosuppressives, Drug Updates, Spondyloarthritis Tagged With: Ankylosing Spondylitis, AS Resource Center

Novel Cathepsin K Inhibitor Promising for OA

June 10, 2020 • By Lara C. Pullen, PhD

Research into the disease-modifying effects of the novel cathepsin K inhibitor MIV-711 suggests it may be effective as a knee OA treatment. In OA patients using the treatment, the study documented statistically significant reductions in bone and cartilage progression…... [Read More]

Filed Under: Conditions, Osteoarthritis Tagged With: cathepsin-K inhibitor, Knee Osteoarthritis (OA), Osteoarthritis, Pain

Researchers Give Update on Janus Kinase (JAK) Inhibitors

May 15, 2020 • By Kimberly Retzlaff

Janus kinase 1 protein.

SNOWMASS VILLAGE, COLO.—Janus kinase inhibitors—or Jakinibs—are a relatively new class of disease-modifying anti-rheumatic drugs (DMARDs) that perform well and have a safety profile comparable to biologics. This group of drugs was the subject of The New Frontier: Comparative Safety of JAK Inhibitors, a presentation given at the ACR Winter Symposium by Kevin L. Winthrop, MD,… [Read More]

Filed Under: Conditions, DMARDs & Immunosuppressives, Rheumatoid Arthritis, Safety Tagged With: baricitinib, janus kinase inhibitor, peficitinib, ruxolitinib, Tofacitinib, upadacitinib, Winter Rheumatology Summit

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