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Search results for: steroid

Study: Most Patients with PMR Aren’t Getting Steroid-Sparing Agents in First 2 Years

Katie Robinson  |  January 25, 2024

A minority of patients with polymyalgia rheumatica (PMR) who were new to rheumatology practice were prescribed steroid-sparing agents through two years of follow-up. This is according to a large, U.S.-based cohort study, published in Arthritis Care & Research, which also found that nearly two-thirds of the patients remained on glucocorticoids beyond one year.1 “Our study…

Filed under:Biologics/DMARDsConditionsDrug UpdatesOther Rheumatic ConditionsResearch Rheum Tagged with:GlucocorticoidsMethotrexatePMR FocusRheumPolymyalgia RheumaticaResearch Reviewsteroid-sparing therapies

Study Probes Corticosteroid Dependence in Polymyalgia Rheumatica

Vivekanand Tiwari, MD, Emily Campbell, MD, Joshua Skydel, MD, Bryan Savage, MD, Monica Dimambro, Todd MacKenzie, PhD, & William F. Rigby, MD  |  January 24, 2024

Background/Purpose Polymyalgia rheumatica (PMR) treatment is primarily based on long-term corticosteroids, which results in significant toxicities. Studies have shown that patients with PMR are exposed to years of corticosteroid treatment.1,2 In a single academic center cohort, we found that 76% of patients remained on steroids at the end of two years.3 In a second cohort…

Filed under:Biologics/DMARDsConditionsDrug UpdatesOther Rheumatic ConditionsResearch Rheum Tagged with:CorticosteroidsGlucocorticoidsPMR FocusRheumPolymyalgia RheumaticaResearch Review

Study Compares Intra-Articular Morphine with Steroids & Placebo in Patients with Chronic Knee Arthritis

Michele B. Kaufman, PharmD, BCGP  |  July 15, 2022

A study from Haibel et al. in patients with chronic knee arthritis found intra-articular morphine did not lead to a significant, short-term reduction in pain compared with placebo and proved inferior to treatment with intra-articular triamcinolone.

Filed under:AnalgesicsConditionsDrug UpdatesOsteoarthritis and Bone DisordersPain Syndromes Tagged with:arthritis painChronic painmorphineosteoarthritis (OA)Pain Syndrome FocusRheumtriamcinolone acetonide

Intra-Articular Steroid/Lidocaine Injection Improves Hip Arthritis Pain, Function

Reuters Staff  |  May 10, 2022

NEW YORK (Reuters Health)—A single injection into the hip of steroid and local anesthetic improved pain and function in patients with hip osteoarthritis in a randomized controlled trial, with most of the benefit seen early after treatment. Researchers at two community-based clinics in England assigned 199 volunteers to receive either an ultrasound guided intra-articular hip…

Filed under:ConditionsOsteoarthritis and Bone Disorders Tagged with:corticosteroid injectionhiphip osteoarthritship painintra-articular corticosteroidsOsteoarthritisPainPain Management

Tocilizumab After Ultra-Short Course Steroids Promising for Newly Diagnosed GCA

Marilynn Larkin  |  July 15, 2021

NEW YORK (Reuters Health)—Tocilizumab induced a slow and lasting remission after an ultra-short pulse (three days) of steroids in newly diagnosed giant cell arteritis (GCA) patients, a proof-of-concept trial shows.1 His early research on cytokines and glucocorticoids led Peter Villiger, MD, of Medical Center Monbijou, Bern, Switzerland, to find ways to reduce steroid use, he…

Filed under:ConditionsDrug UpdatesVasculitis Tagged with:GCAgiant cell arteritis (GCA)IV tocilizumabSteroidstocilizumab

Study: Can Avacopan Replace Steroids in ANCA-Associated Vasculitis?

Ruth Jessen Hickman, MD  |  May 13, 2021

A phase 3 trial described in The New England Journal of Medicine (NEJM) highlights the potential of a C5a receptor inhibitor, avacopan, for anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis.1 Avacopan may potentially offer a steroid-sparing option for the treatment of this serious disease. Current Treatment of ANCA-Associated Vasculitis Morbidity and mortality from ANCA-associated vasculitis have…

Filed under:ConditionsDrug UpdatesResearch RheumVasculitis Tagged with:ANCA-Associated VasculitisavacopanGlucocorticoidsSteroids

Denosumab Has Edge on Alendronate for Steroid-Induced Bone Loss

Matthew Phelan  |  March 10, 2021

NEW YORK (Reuters Health)—Long-term glucocorticoid users see greater gains in spine bone-mineral density when treated with the monoclonal antibody denosumab vs. oral alendronate, a small clinical trial shows. The drug also proved superior at lowering bone-turnover markers at 12 months, researchers in Hong Kong report in Bone.1 “Denosumab may be considered as an alternative first-line…

Filed under:Drug Updates Tagged with:alendronatebone lossbone mineral density (BMD)denosumabGlucocorticoids

Sports Doctors May Accidentally Prescribe Banned Steroids

Lisa Rapaport  |  March 4, 2020

(Reuters Health)—Sports physicians routinely prescribe corticosteroids to athletes for conditions, such as inflammation, asthma and allergies, but not all of them know which forms of these drugs are banned under anti-doping rules, a study suggests. The survey of 603 physicians from 30 countries found four in five prescribe oral corticosteroids to athletes, one of the…

Filed under:Drug Updates

Trial Data Reveals the Limitations of Steroids in Giant Cell Arteritis Therapy

Thomas R. Collins  |  September 20, 2018

AMSTERDAM—Just how seldom prednisone is successful at inducing remission in giant cell arteritis (GCA), despite such a long history of use for the disease, is one of the many lessons to emerge from the data in the GiACTA trial, said the principal investigator of the trial, which is the largest ever in GCA and is…

Filed under:ConditionsVasculitis Tagged with:giant cell arteritis (GCA)Steroidstocilizumab

Study Urges Caution with Steroid Injections for Hip Osteoarthritis

Mary Beth Nierengarten  |  April 26, 2018

For patients with hip osteoarthritis (OA), pain management and maintaining function are primary therapy goals. Current guidelines offer recommendations on nonpharmacologic and pharmacologic approaches to addressing these issues in hip OA. For patients in whom pharmacologic management is considered, the use of intra-articular steroid injections is one option. In its 2012 guidelines (the most current…

Filed under:Osteoarthritis and Bone Disorders Tagged with:hipsteroid injection

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