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You are here: Home / ACR Convergence 2020 / Gout Resource Center

Gout Resource Center

Earlier this year, the ACR released a new guideline for the management of gout, leaving some rheumatologists unsure what to recommend to their patients. Clearing up the confusion was one aim of the session, Evidence-Based Guidance for Optimizing Gout Management. Learn what the experts had to say.

Ethan Craig, MD, MHS, an assistant professor of clinical medicine with the Division of Rheumatology at the University of Pennsylvania, Philadelphia, a rheumatologist at the Corporal Michael J. Crescenz VA Medical Center and the associate physician editor of The Rheumatologist, reviewed the research abstracts related to gout presented at ACR Convergence 2020 and talks about why they stand out.

Below, explore our coverage of additional gout information presented at ACR Convergence 2020, selected by Physician Editor Philip Seo, MD, MHS, as well as selected content from The Rheumatologist’s collection of research reviews, case reports and clinical articles on advances in the diagnosis and management of gout.

ACR Convergence 2020: Gout

Reducing Immunogenicity of Pegloticase (RECIPE) with Concomitant Use of Mycophenolate Mofetil in Patients with Refractory Gout—a Phase II Double Blind Randomized Controlled Trial

Background/Purpose: Pegloticase, a recombinant, pegylated uricase, is used for treatment of gout in patients who fail oral urate lowering therapy (ULT). Despite successful reduction of urate levels and flares, its use is limited due to immunogenicity, leading to infusion reactions.1 Co-administration of an immunomodulatory agent may mitigate this loss of efficacy and concern for drug-related… [Read More]

Dr. Ethan Craig Picks His Favorite Gout Abstracts from ACR Convergence 2020

In light of the release of the ACR’s new gout guideline, it’s not surprising that 50 abstracts of studies on various aspects of gout were accepted at ACR Convergence 2020. Here, we highlight just a few:... [Read More]

Optimize Gout Management with the Latest Evidence-Based Guidance

ACR Convergence 2020—In May 2020, the ACR published its updated guideline for the management of gout.1 It followed on the heels of a 2017 gout guideline published by the American College of Physicians.2 Although the guidelines provide similar recommendations on the treatment of acute gout, they differ importantly in the use of uric acid-lowering therapy… [Read More]

FAST Results for Febuxostat Safety in Gout Patients

ACR CONVERGENCE 2020—The results of a post-authorization study comparing the cardiovascular safety of febuxostat vs. allopurinol were presented in a late-breaking abstract session at the ACR’s fully virtual annual meeting on Monday, Nov. 9. Cardiologist Thomas MacDonald, MD, FRCP, MBChB, clinical professor (teaching and research) of molecular and clinical medicine, University of Dundee School of… [Read More]

Gout: The State of the Science

In light of the release of the ACR’s new gout guideline, it’s not surprising that 50 abstracts of studies on various aspects of gout were accepted at ACR Convergence 2020. Here, we highlight just a few:... [Read More]

The ACR Releases a New Gout Guideline

Akarat Phasura / shutterstock.com

In May, the ACR released a new treatment guideline for the management of gout for simultaneous publication in Arthritis & Rheumatology and Arthritis Care & Research.1 Based on evidence from more than 130 published studies, the guideline makes a total of 42 recommendations—of which 16 are strong: It has 27 recommendations for urate-lowering therapy (ULT)… [Read More]

Research, Case Reports & More

High Opioid Prescription Rates Seen in Emergency Department-Treated Gout

Acute gout can be very painful, causing patients to seek treatment in the emergency department. A retrospective study of pain interventions for gout in Rhode  Island found that nearly 30% of patients received prescriptions for opioid medications over 30 months. Of these prescriptions, over 80% were for patients who had never been exposed to opioids… [Read More]

Bringing Consistency to Gout Terms & Concepts

The umbrella term crystalline disease covers arthritic conditions caused by deposition of crystals and associated inflammatory response, including erythema, edema and intense pain. The two most common crystal-induced arthropathies are gout, an arthritis secondary to inflammation caused by the presence of monosodium urate (MSU) crystals formed through high levels of serum urate, and calcium pyrophosphate… [Read More]

The ACR Releases a New Gout Guideline

Akarat Phasura / shutterstock.com

In May, the ACR released a new treatment guideline for the management of gout for simultaneous publication in Arthritis & Rheumatology and Arthritis Care & Research.1 Based on evidence from more than 130 published studies, the guideline makes a total of 42 recommendations—of which 16 are strong: It has 27 recommendations for urate-lowering therapy (ULT)… [Read More]

The Latest Advances in Sjögren’s, Scleroderma, RA, Gout & More

ATLANTA—At the ACR/ARP 2019 Annual Meeting, several widely renowned experts across an array of specialty subjects provided a comprehensive and compelling review of advances in the understanding, diagnosis and treatment of a number of rheumatologic conditions. Sjögren’s Syndrome Frederick Vivino, MD, FACR, chief of rheumatology at Penn Presbyterian Medical Center and professor of clinical medicine… [Read More]

New Study Identifies How Big a Role Diet Plays in Hyperuricemia

Living like a king has its price. And while kings and queens are primarily something of yesteryear, the vast majority of those living in reasonably wealthy nations can now live like kings. Now, back to that price. Gout, once known as the disease of kings, has been around at least since the time of the… [Read More]

Sodium-Glucose Cotransporter-2 Inhibitors May Decrease Gout Risk in Some Patients

Recent research assessed the risk of gout in patients with type 2 diabetes mellitus prescribed sodium-glucose cotransporter-2 (SGLT2) inhibitors compared with those prescribed a glucagon-like peptide-1 (GLP-1) agonist. The study found patients on the SGLT2 inhibitor had a lower rate of gout, suggesting SGLT2 inhibitors may actually reduce the risk of gout among this patient population…... [Read More]

Pegloticase & Methotrexate Combination Therapy May Benefit Patients with Uncontrolled Gout

Patients with uncontrolled gout may benefit from a combination of pegloticase and methotrexate therapy, according to a small, retrospective study…... [Read More]

Potential Link Between OA & Gout

Monosodium urate (MSU) crystal formation, deposition and gout flares frequently affect joints that have been damaged or are affected by osteoarthritis. These researchers examined the effects of human cartilage homogenates on MSU crystallization and MSU crystal-induced inflammation…... [Read More]

Case Report: A Patient with Gout Develops Granulomatous Hepatitis

A CT of the abdomen demonstrated numerous hypodense lesions present in both lobes of the liver, with the largest lesion measuring 2.0 x 3.1 cm.

Case Presentation A 45-year-old man with crystal-proven gout, poorly controlled diabetes and chronic kidney disease was lost to follow-up for six years and presented back to the VA clinic in the midst of a gout flare. He stated he had continued taking 100 mg of allopurinol daily, but his serum urate level was 13.8 mg/dL…. [Read More]

Insight into Achieving & Maintaining Target Serum Urate Levels in Gout Patients

A recent study advances the understanding of factors associated with a target serum urate level of 6 mg/dL or less. Researchers found such factors as having a rheumatologist as the main provider of gout care contributed to achieving and maintaining this outcome. However, the presence of co-morbidities lowered a patient’s chances for achieving the target serum urate level, even with allopurinol use…... [Read More]

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