Gene Signatures in IgG4-Related Disease

In their discussion the authors write, “We show the importance of the T and B cell axis with molecular profiling across RD-SG, RD-nonSG and RF, as well as features that distinguish these three diseases. Future work seeks to better understand the molecular mechanisms at relapse or recurrence following steroid reduction in these patients.”

Lara C. Pullen, PhD, is a medical writer based in the Chicago area.

Reference

1. Higgs BW, Liu Y, Guo J, et al. High-throughput RNA sequencing reveals distinct gene signatures in active IgG4-related disease. Sci Rep. 2017 Dec 14;7(1):17567. doi: 10.1038/s41598-017-17602-9.