‘Metabolism is relevant in understanding how macrophages work,’ Dr. Camara said.
“From several different standpoints—skin disease, interstitial lung disease, pulmonary hypertension—we see this recurrent theme of macrophages somehow having an important role in pathogenesis—or at least the most obvious role,” he said. However, what activates them remains unclear.
“There are lots of different kinds of macrophages and dendritic cells in different sites,” Dr. Lafyatis said. “They’re different at different sites. They’re different when they start, and then they’re going to change. That’s one of the questions: How do they change as you have disease come on? All of these things are difficult questions to answer.”