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Lara C. Pullen, PhD

Lara C. Pullen, PhD, is a medical writer with a PhD in microbiology/immunology from Northwestern University’s Feinberg School of Medicine. As a medical writer she has covered topics as diverse as diabetes, cardiovascular disease, and autism. Her favorite subject, however, is the role of the immune system in health and disease. Dr. Pullen is also the mother of three children, the youngest of whom has Prader-Willi Syndrome (PWS). She is an active member of the PWS community and a thought leader on the importance of the ketogenic diet for this patient population.

Articles by Lara C. Pullen, PhD

Ankylosing Spondylitis Patients May Have Worse Oral Health

Lara C. Pullen, PhD  |  February 28, 2019

Patients with ankylosing spondylitis (AS) may have worse overall oral health than the general population. A recent study revealed an association between AS and oral ulcers…

Extracellular Vesicles May Play an Important Role in Seropositive RA Disease Severity

Lara C. Pullen, PhD  |  February 21, 2019

In a study, researchers found extracellular vesicles may contribute to the greater disease severity typically seen in patients with seropositive rheumatoid arthritis (RA). Specifically, in these patients, extracellular vesicles can activate mononuclear phagocytes and induce proinflammatory cytokines in vitro…

Rheumatologists Debate Hydroxychloroquine Dosing Guidelines for Lupus

Lara C. Pullen, PhD  |  February 18, 2019

CHICAGO—The correct dosing of hydroxychloroquine (HCQ) for systemic lupus erythematosus (SLE) is a concern of all rheumatologists. Petros Efthimiou, MD, clinical professor of medicine at New York University, New York City, opened the Great Debate of the 2018 ACR/ARHP Annual Meeting by stating, “Today, we will be discussing a critical clinical problem that affects everyone’s…

What to Do with Erosive, Inflammatory Osteoarthritis

Lara C. Pullen, PhD  |  February 17, 2019

CHICAGO—Is erosive, inflammatory osteoarthritis (EOA) a separate condition from osteoarthritis (OA)? Roberta Ramonda, MD, PhD, a rheumatologist at the University of Padova, Italy, spoke at the 2018 ACR/ARHP Annual Meeting on the clinical presentation of EOA and how it differs from OA. EOA is characterized by a frequent aggressive clinical course and occurs most often…

Alterations in Macrophage Activation May Signal a Lupus Flare

Lara C. Pullen, PhD  |  February 11, 2019

New data suggest myeloid cells in SLE patients skew B and T cell activation status toward the M1 proinflammatory phenotype, thereby directing SLE flares and remission…

Early Onset of Primary Sjögren’s Syndrome May Carry a Worse Prognosis

Lara C. Pullen, PhD  |  February 4, 2019

Research has found age at disease onset has an impact on prognosis for patients with primary Sjögren’s syndrome. In the study, early onset primary Sjögren’s syndrome was associated with severe, systemic disease and development of lymphoproliferative disease…

PAD2 & PAD4 Modulate Immune Response in TLR-7-Dependent Lupus

Lara C. Pullen, PhD  |  January 28, 2019

A study in mice suggests that targeting peptidyl arginine deiminases in lupus patients may have a therapeutic role in T cell-mediated diseases, affecting innate and adaptive immunity, as well as modulating dysregulated toll-like receptor 7-dependent immune responses…

Do Osteoporosis Screening Guidelines Meet Patient Needs?

Lara C. Pullen, PhD  |  January 21, 2019

A recent study found that clinical practice guidelines for osteoporosis screening vary in quality and recommendations—even within the same country. Assessing guidelines from 13 countries, researchers found osteoporosis screening standards have not improved over time and many fail to include patients in guideline development…

Intensive Patient Education May Not Be Helpful for Acute Low Back Pain

Lara C. Pullen, PhD  |  January 14, 2019

Education with recommended first-line care may not improve pain outcomes in patients with acute low back pain. When comparing patients who received education with those who received professional consultation without information or advice, researchers found patient education was no more effective than placebo at reducing depression or incidence of chronic low back pain…

Intronic Polymorphism Associated with Risk of Neurological Disorders in SLE

Lara C. Pullen, PhD  |  January 8, 2019

Patients who develop neuropsychiatric symptoms of SLE have a small nucleotide polymorphism (SNP) in an intron in a Ca++ ion channel gene that influences some, but not all, events regulated by Ca++. The SNP appears to influence activation induced apoptosis rates and cytokine production, specifically IL-4, in a disease- and genotype-specific manner…

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