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Lara C. Pullen, PhD

Lara C. Pullen, PhD, is a medical writer with a PhD in microbiology/immunology from Northwestern University’s Feinberg School of Medicine. As a medical writer she has covered topics as diverse as diabetes, cardiovascular disease, and autism. Her favorite subject, however, is the role of the immune system in health and disease. Dr. Pullen is also the mother of three children, the youngest of whom has Prader-Willi Syndrome (PWS). She is an active member of the PWS community and a thought leader on the importance of the ketogenic diet for this patient population.

Articles by Lara C. Pullen, PhD

Running Barefoot May Protect Against Some Musculoskeletal Injuries

Lara C. Pullen, PhD  |  May 23, 2016

Running barefoot may conjure images of summer and childhood, but since Abebe Bikila of Ethiopia set a world record running barefoot in the marathon in the 1960 Olympic Games in Rome (Olympic gold medal in a world-record 2:15:16.2), many runners have adopted the style. A recent study found that running barefoot may be associated with significantly fewer overall musculoskeletal injuries than running shod…

Autoantibodies in Pregnant Woman May Put Infant at Risk for Neonatal Lupus Erythematosus

Lara C. Pullen, PhD  |  May 16, 2016

A recent case study revealed that an infant from a donor egg developed neonatal lupus erythematosus (NLE) and a congenital heart block, which may have been due to the presence of antibodies to Ro and La in the birth mother—not the genetic mother. The results suggest that a gestational mother with a history of autoimmune disease is sufficient to trigger the pathology of NLE…

Patients with Lupus: Plasmacytoid Dendritic Cells Fail to Induce Regulatory B Cells

Lara C. Pullen, PhD  |  May 9, 2016

A recent study found that plasmacytoid dentricitic cells (pDCs) control the differentiation of immature B cells into regulatory B (Breg) cells or plasmablast, depending on the concentration of IFNα. For patients with SLE, researchers found that immune regulatory feedback between pDCs and Breg cells is dysfunctional, with the exception of patients who respond to rituximab…

Researchers Work to Untangle the Relationship Between Blood Lipids, Bone Health & Diet

Lara C. Pullen, PhD  |  May 2, 2016

A recent editorial examined research findings on how low levels of high-density lipoprotein (HDL) in the blood affect bone health, resulting in cartilage dysfunction and the development of osteoarthritis (OA). Authors note that a high-fat diet in mice with HDL deficiency resulted in OA development; thus, they conclude that in patients with metabolic syndrome, HDL may have a causative relationship to OA…

Innate Immune Response Enters Center Stage for Inflammatory Eye Disease

Lara C. Pullen, PhD  |  April 25, 2016

Researchers suspect the C-type lectin receptor (CLR) mincle may play a role in experimental autoimmune uveoretinitis. A new study linked CLR mincle to Card9-signaling events and IL-1, resulting in inflammation…

Platelet-Rich Plasma Therapy May Treat Degenerative Tendinopathies & Pain

Lara C. Pullen, PhD  |  April 18, 2016

A recent small-scale study showed that patients who received platelet-rich plasma therapy for tendon healing experienced clinically important improvements in pain and disability compared with placebo. Additionally, MRI showed that some participants had improvement in the pathoanatomy of the rotator cuff six months after treatment…

Carpal Tunnel Syndrome: Is Post-Surgical Rehabilitation Helpful?

Lara C. Pullen, PhD  |  April 11, 2016

A recent research review compared the results of various studies on rehabilitation treatments, including immobilization, exercise and cold therapy, for patients with carpal tunnel syndrome after surgery. The authors concluded that little evidence supports the effectiveness of rehabilitation techniques, and many of the studies reviewed have similar limitations…

Vitamin D May Improve Heart Health in Patients with Lupus

Lara C. Pullen, PhD  |  April 4, 2016

A new study has found that treating patients who have systemic lupus erythematosus (SLE) with vitamin D decreases cardiovascular risk in these patients—specifically by modifying the body’s endothelial repair mechanisms. Researchers found myeloid angiogenic cells in this patient population presented with a global impairment, including decreased migration and angiogenic capacity…

Researchers Find the Switch that Underlies Macrophage Metabolism

Lara C. Pullen, PhD  |  March 28, 2016

During pro-inflammatory stimulation, a recent study found HIF1α—not Myc—is required for the regulation of glycolysis in macrophages. Researchers examined macrophages and the distinct transcriptional programs engaged in response to mitogenic and pro-inflammatory stimulation…

Fibromyalgia & Bipolar Spectrum Disorder: A Shared Pathophysiology May Lead to Better Drug Targets

Lara C. Pullen, PhD  |  March 21, 2016

Patients suffering from fibromyalgia and those suffering from bipolar spectrum disorder experience similar symptoms. Research suggests that these diseases may share a pathophysiological process, particularly a similar impairment in the prefrontal-limbic networks of the brain. A new editorial addresses how a better understanding of the potential shared biological underpinning of these diseases could result in unique drug targets…

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