Rheumatologists are already familiar with one mosquito-borne virus, chikungunya, whose presentation mimics arthritis. Now, with its recent spread to Puerto Rico and the Southeastern U.S., Zika, another mosquito-borne virus, has become an international public health concern. Sexual transmission of the virus was recently confirmed, expanding the virus’s threat…
Lara C. Pullen, PhD, is a medical writer with a PhD in microbiology/immunology from Northwestern University’s Feinberg School of Medicine. As a medical writer she has covered topics as diverse as diabetes, cardiovascular disease, and autism. Her favorite subject, however, is the role of the immune system in health and disease. Dr. Pullen is also the mother of three children, the youngest of whom has Prader-Willi Syndrome (PWS). She is an active member of the PWS community and a thought leader on the importance of the ketogenic diet for this patient population.
Articles by Lara C. Pullen, PhD
Is Arthroscopic Meniscal Surgery Effective?
A recent review examined the effectiveness of arthroscopic mensical surgery in treating meniscal injuries. Researchers determined that little evidence exists to support the use of arthroscopic meniscal surgery and more studies that directly compare it with nonoperative treatments are needed…
Gout Treatment & Care Remain Suboptimal
A recent analysis compared the care of patients with RA with that received by patients with gout, finding that hospitalization and costs for patients with gout have increased, but both are decreasing for patients with RA. Unlike RA, significant advances in treatment have not been made for gout, despite its increasing prevalence, and patients may land in the hospital unnecessarily…
Patients with Active RA Have Higher Drug Efflux Transporter Activity
New research examined the peripheral blood in patients with rheumatoid arthritis to investigate the association between disease activity, treatment and the functional activity of ABCB1 and ABCG2 drug efflux transporters. Results showed that transporter activity may correlate with increased disease activity and persist unrelated to treatment for as long as six months in some patients…
Exercise Therapy May Take the ‘Tired’ Out of Chronic Fatigue Syndrome
A recent review has expanded the current thinking about the benefits of exercise therapy for patients with chronic fatigue syndrome. Study participants experienced improved sleep, physical function and self-perceived general health…
Tendinitis & Other Weight Training-Related Injuries
With the increased popularity of CrossFit and other weight-training sports, a recent review examined the risk of injury associated with these activities. Using data from mostly retrospective studies, researchers determined that weight-training sports have a lower risk of injury than team sports, with bodybuilding having the lowest injury rate…
High-Salt Diet May Trigger Gene Silencing & a Lupus Phenotype
New research has demonstrated that a high-salt diet may increase the differentiation of follicular helper T cells (Tfh). A high-salt diet also increased lupus features in MRL/lpr mice, suggesting that the genes that increased expression in response to salt intake were similar to the genes that had increased expression in lupus CD4+ T cells…
Plasmabast Responses Provide a Signature for Lupus Disease Activity
A recent study documented blood transcriptional profiles in pediatric patients with systemic lupus erythematosus (SLE), finding that plasmablast signatures were the most robust biomarker of SLE disease activity. Researchers were further able to stratify patients into groups on the basis of molecular correlates, which may aid in personalizing SLE treatment and identifying biomarkers that can predict occurrence and frequency of flares…
Ultrasound May Be Useful for Grading Rotator Cuff Tendinopathy
Researchers have developed procedures and assessed their efficacy for the use of ultrasound images to measure the inter-rater reliability of the measurement of structural changes in the tendon of patients with supraspinatus tendinopathy. The standardized procedures proved useful in evaluating patients…
MicroRNA Mediates Gene Regulation That Underlies JIA Pathology
Through the use of large-scale transcriptome analysis, researchers have gained insight into the role of innate immunity in juvenile idiopathic arthritis (JIA) pathology. Specifically, transcriptomes of neutrophils in chronic inflammatory states demonstrate extensive network rewiring caused by microRNA, suggesting a role for alternative splicing in JIA pathogenesis…
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