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Lara C. Pullen, PhD

Lara C. Pullen, PhD, is a medical writer with a PhD in microbiology/immunology from Northwestern University’s Feinberg School of Medicine. As a medical writer she has covered topics as diverse as diabetes, cardiovascular disease, and autism. Her favorite subject, however, is the role of the immune system in health and disease. Dr. Pullen is also the mother of three children, the youngest of whom has Prader-Willi Syndrome (PWS). She is an active member of the PWS community and a thought leader on the importance of the ketogenic diet for this patient population.

Articles by Lara C. Pullen, PhD

Oxidized Mitochondrial DNA May Contribute to Inflammation in SLE

Lara C. Pullen, PhD  |  March 14, 2016

New research examines how the generation of reactive oxygen species and neutrophil extracellular traps may break down the protective mechanisms of mitochondrial DNA, resulting in NETosis in people with autoimmune disease. They found oxidized mitochondrial DNA may contribute to inflammation in such diseases as systemic lupus erythematosus by upregulating type I interferon signatures…

Do Bisphosphonates Increase Risk of Carpal Tunnel Syndrome?

Lara C. Pullen, PhD  |  March 7, 2016

In a large-scale study, researchers demonstrated that the use of bisphosphonates in postmenopausal women is associated with an increased risk of carpal tunnel syndrome, in addition to other known risks (e.g., incapacitating bone, joint and/or musculoskeletal pain, and osteonecrosis of the jaw)…

Clinical Trials Confirm Secukinumab Can Effectively Treat Ankylosing Spondylitis

Lara C. Pullen, PhD  |  February 29, 2016

Secukinumab, an anti-interleukin-17A monoclonal antibody, has successfully completed multiple clinical trials, which found the intravenous treatment may be safe and effective for treating patients with active ankylosing spondylitis…

Insight into Crosstalk Between Bone & Immune Systems

Lara C. Pullen, PhD  |  February 22, 2016

Osteoimmunology is an emerging field that focuses on the interaction between bone and the immune system. CD4+ T cells play an important role in the bone marrow and modulate the differentiation of bone-resorbing osteoclasts. This article reviews the role of CD4+ T cells as an osteoclastogenic population in inflammatory bowel disease…

Study Targets Osteoclast Receptor to Inhibit Osteoclastogenesis

Lara C. Pullen, PhD  |  February 15, 2016

The results of a new study examined the human osteoclast-associated receptor may aid in the development of therapeutic matrikines to control aberrant osteoclastogenesis in some autoimmune diseases…

Gut-on-a-Chip Provides Insight into Microbiome & Intestinal Inflammation

Lara C. Pullen, PhD  |  February 8, 2016

Researchers have created a microdevice with Caco-2 intestinal epithelial cells to aid in studying the human gut microbiome’s role in homeostasis, immune modulation and pathology. Using this gut-on-a-chip, researchers were able to examine in detail the processes they think result in chronic intestinal inflammation…

Researchers Target Altered T Cell Metabolism in SLE to Reverse Lupus Immuno-Phenotype

Lara C. Pullen, PhD  |  February 1, 2016

A recent study on systemic lupus erythematosus examined the effects of metabolic modulators on the disease’s abnormal T cell metabolism. Using a combination therapy of metformin and 2-deoxy-D-glucose, researchers were able to normalize CD4+ T cell functions and restore defective IL-2 production in mice…

Large Group Study of Systemic JIA Patients Provides Insight into Disease Pathology

Lara C. Pullen, PhD  |  January 25, 2016

In a large group genetic analysis, researchers identified an association between the class II HLA region, including HLA-DRB1*11, and systemic juvenile idiopathic arthritis (sJIA), implicating adaptive immune molecules in sJIA’s pathogenesis and reinforcing its unique genetic position among JIA subtypes…

Study Uncovers Tet2’s Role in Resolving Inflammation

Lara C. Pullen, PhD  |  January 11, 2016

When investigating the role of epigenetic modifiers in inflammatory response, researchers found that Tet2 acts at the chromatin level to help resolve inflammation in both dendritic cells and macrophage, repressing the transcription of IL-6…

ACPA-Positive & ACPA-Negative Patients with RA: The Difference Begins in the Lungs

Lara C. Pullen, PhD  |  January 4, 2016

A new study from Stockholm, Sweden, strengthens the link between the lungs and anti-citrullinated protein antibody (ACPA)–positive RA. After analyzing the bronchial tissue of untreated patients with early RA, researchers found the patients’ lungs had signs of immune cell accumulation and activation…

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