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Subcategories:Axial SpondyloarthritisClinical Criteria/GuidelinesGout and Crystalline ArthritisMyositisOsteoarthritis and Bone DisordersOther Rheumatic ConditionsPain SyndromesPediatric ConditionsPsoriatic ArthritisRheumatoid ArthritisSjögren’s DiseaseSoft Tissue PainSystemic Lupus ErythematosusSystemic SclerosisVasculitis

Biomarkers Differentiate Crohn’s Disease from Ulcerative Colitis

Marilynn Larkin  |  June 4, 2016

NEW YORK (Reuters Health)—Newly identified biomarkers could aid in the diagnosis of inflammatory bowel disease (IBD) and help guide therapy, Canada-based researchers report. Accurately differentiating between Crohn’s disease (CD) and ulcerative colitis (UC) is important for ensuring early and appropriate treatment. However, the conditions can’t be reliably distinguished based on clinical symptoms, site of disease,…

Bacterial Curli Amyloid: Researchers Examine the Role of Bacterial Infection in Lupus Pathology

Richard Quinn  |  June 3, 2016

New research has found that the amyloid protein curli triggers immune activation and autoantibody production in lupus-prone and wild-type mice. Stefania Gallucci, MD, says these results provide insight into the mechanisms of bacterial infection that may result in lupus…

Diffuse Alveolar Hemorrhage Secondary to Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: Predictors of Respiratory Failure and Clinical Outcomes

Arthritis & Rheumatology  |  June 1, 2016

A variety of immune and nonimmune pathophysiologic mechanisms causing the disruption of alveolar capillaries with bleeding into the alveolar spaces can lead to diffuse alveolar hemorrhage (DAH). Immune-mediated mechanisms can cause DAH with or without the presence of capillaritis. The antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) syndromes—granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA)—are the…

Inflammation May Sensitize Patients with Osteoarthritis to Pain

Lara C. Pullen, PhD  |  May 30, 2016

A recent editorial in Arthritis & Rheumatology explored the role of sensitization, not nociception, as a key mechanism of pain for patients with knee OA, as well as inflammation’s role in pain perception. Recent research of synovitis and joint effusion supports the idea that early prevention or treatment of sensitization may be paramount to reducing long-term pain in patients with knee OA…

Massage May Be an Option for Pain Relief

Andrew M. Seaman  |  May 29, 2016

(Reuters Health)—Massage is better than nothing for pain relief, according to a new review. The therapy may also be an acceptable choice for people considering other options, such as acupuncture and physical therapy. “It should be considered at least for musculoskeletal pain as a viable option in the mix of pain management techniques in these areas,”…

Lilly Says New Type of Pain Drug Could Reduce Need for Opioids

Ransdell Pierson  |  May 28, 2016

(Reuters)—Eli Lilly and Co. on Tuesday said it and partner Pfizer Inc. aim to seek approval by 2018 for a new type of pain drug that could be an alternative to opioids for osteoarthritis, chronic back pain and cancer pain. The Indianapolis drugmaker said tanezumab, given by injection every eight weeks, could be a far…

Osteoarthritis Treatments: Monoclonal Antibody Starts Clinical Trial & Fasinumab Promising for Treating Pain

Michele B. Kaufman, PharmD, BCGP  |  May 25, 2016

Recent clinical trials have evaluated the efficacy of GSK3196165, a monoclonal antibody, and fasinumab, a nerve growth factor antibody, in treating patients with osteoarthritis and pain…

Running Barefoot May Protect Against Some Musculoskeletal Injuries

Lara C. Pullen, PhD  |  May 23, 2016

Running barefoot may conjure images of summer and childhood, but since Abebe Bikila of Ethiopia set a world record running barefoot in the marathon in the 1960 Olympic Games in Rome (Olympic gold medal in a world-record 2:15:16.2), many runners have adopted the style. A recent study found that running barefoot may be associated with significantly fewer overall musculoskeletal injuries than running shod…

From the Expert: Dr. Michael Weisman Discusses the Challenges of Enthesitis

Richard Quinn  |  May 20, 2016

A recent review in Arthritis & Rheumatology examined advances in addressing the pathophysiology, genetics and treatment of enthesitis for patients with spondyloarthritis. And author Michael Weisman, MD, notes that challenges remain in understanding the genetics and triggers of enthesitis…

Baricitinib Has Promising Clinical Trial Results for Treating RA

Michele B. Kaufman, PharmD, BCGP  |  May 18, 2016

Recent clinical trials have shown that baricitinib is safe and effective for treating patients with rheumatoid arthritis who have proved non-responsive to multiple biologic treatments…

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