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Systemic Lupus Erythematosus

Lupus B Cell Research Points Toward Targeted Therapies

Susan Bernstein  |  January 19, 2018

SAN DIEGO—B cell signaling goes awry in many patients with systemic lupus erythematosus (SLE), triggering pathogenic autoimmune responses and clinical disease. At the Rheumatology Research Foundation’s 2017 Evelyn V. Hess Memorial Lecture, held on Nov. 5 at the ACR/ARHP Annual Meeting, researcher Ignacio Sanz, MD, discussed B cells’ role in this complex disease. Because lupus…

New Lupus Classification Criteria Presented at ACR/ARHP Annual Meeting

Susan Bernstein  |  January 19, 2018

SAN DIEGO—Proposed classification cri­teria for systemic lupus erythematosus (SLE), which are supported but not yet approved by the ACR and EULAR, debuted on Nov. 7 at the 2017 ACR/ARHP Annual Meeting. An international steering committee developed and validated the criteria, with patient input and the consensus of more than 150 global SLE experts. Researchers referred…

Case Review: Lupus Patient with Acute Disseminating Encephalomyelitis

Teresa Sosenko, MD, Anca Musetescu, MD, PhD, Neha Gandhi, MD, Scott Friedstrom, MD, & Diana Girnita, MD, PhD  |  January 19, 2018

Systemic lupus erythematosus (SLE) is an autoimmune-mediated rheumatic disease characterized by multisystem involvement that can cause significant morbidity and mortality. Acute disseminated encephalomyelitis (ADEM) is a rare, fulminant, autoimmune-mediated, demyelinating disease involving the white matter of the central nervous system (CNS), and is considered a manifestation of neuropsychiatric lupus. Few reported cases involve SLE and…

Cardiovascular Disease Rate Differs Between SLE Patients of Different Races, Ethnicities

Kurt Ullman  |  December 18, 2017

A recent epidemiologic study of patients with systemic lupus erythematosus (SLE) investigated racial and ethnic differences in the risk for cardiovascular disease (CVD). Among SLE patients enrolled in Medicaid, the risk for myocardial infarction (MI) was lower in Hispanics and Asians compared with whites, and the risk of stroke was higher in blacks and Hispanics…

Strong Statistical Association Found Between Trauma and Lupus

Elizabeth Hofheinz, MPH, MEd  |  December 18, 2017

They say the body remembers what the mind wants to forget. For those who have experienced trauma, not only does the body remember, in some cases it works on making things worse. Such is the situation with trauma and lupus, says a new study published in Arthritis & Rheumatology in October. The study, titled, “Association…

New Classification Criteria for SLE: Proposed ACR/EULAR Criteria aim for high sensitivity & specificity

Susan Bernstein  |  December 15, 2017

SAN DIEGO—The proposed classification criteria for systemic lupus erythematosus (SLE), supported but not yet approved by the ACR and EULAR, were debuted on Nov. 7 at the 2017 ACR/ARHP Annual Meeting. An international steering committee developed and validated the criteria, with patient input and the consensus of more than 150 global SLE experts. Rheumatology researchers…

The Pop Star Effect & Lupus: Celebrity Cred May Help Raise Awareness of Rheumatic Disease

Richard Quinn  |  December 15, 2017

This year, Selena Gomez underwent a kidney transplant as a result of damage from living with lupus. But how can this celebrity story aid rheumatologists? Many see it as an opportunity to raise awareness or create a dialogue with primary care physicians. But for lupus patients, it can be a reminder for them to take control of their own wellbeing, according to rheumatologist Susan Manzi, MD, MPH…

Multimodal Imaging May Uncover Neural Mechanisms in Pediatric Neuropsychiatric Lupus

Carina Stanton  |  December 1, 2017

In clinical practice, many unknowns exist about how SLE affects the brain—particularly in children. To help these young children battling pediatric SLE, Andrea Knight, MD, MSCE, is examining how advanced neuroimaging techniques may uncover potential inflammatory and non-inflammatory mechanisms of neuropsychiatric dysfunction in lupus…

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Research Targets Interferon Alpha in New Treatment Approach for CNS Lupus

Mary Beth Nierengarten  |  November 9, 2017

RETRACTED Editor’s note: The study this article reported on was retracted by the researchers. Key aspects could not be replicated, and they said, “Most importantly, the findings from behaviour studies and sequencing of microglia isolated from 564Igi autoimmune mice as shown in Figs. 1a, b, d and 3a, b are not substantiated upon further analysis…

Lupus Survival Is Improving Slowly

Will Boggs, MD  |  October 30, 2017

NEW YORK (Reuters Health)—Systemic lupus erythematosus (SLE) mortality has declined during the past 46 years in the U.S.—but more slowly than mortality in the general population, according to a nationwide study. “Based on our experience in the clinic and according to previous reports showing improvement in the short-term (five- to 10-year) survival in lupus, I…

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