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Systemic Lupus Erythematosus

Potential Biomarker for APS Identified

Lara C. Pullen, PhD  |  October 23, 2017

New research examines the role of factor Xa in the pathology of antiphospholipid syndrome (APS) and systemic lupus erythematosus-associated APS. Researchers found that FXa stimulation was mediated by protease-activated receptors and enhanced by IgG from FXa reactive antibody positive patients, which may make IgG FXa reactivity a novel biomarker for future research…

New Studies Examine Impact of Poverty, Race, Ethnicity in Patients with SLE

Elizabeth Hofheinz, MPH, MEd  |  October 17, 2017

To correctly address a problem, one must have a handle on its nuances—a clear understanding of what is linked and how. And thus far, when it comes to lupus, we haven’t reached the point of understanding those intricacies. Things are heading in the right direction, however, with two new studies that get us much closer…

The ACR, EULAR Partner to Refine Classification System, Develop New SLE Criteria

Thomas R. Collins  |  October 17, 2017

MADRID—Systemic lupus erythematosus (SLE) experts in North America and Europe are working together to refine the classification system for the disease, with the goal of producing a new set of criteria that is simpler to use and more scientifically rigorous than any classification approach previously published, speakers involved with the process said at the 2017…

Bipolar Disorder, Nailfold Capillaroscopy Score, Urban Location Among Risk Factors for Developing Lupus

Thomas R. Collins  |  October 17, 2017

MADRID—Researchers have found that systemic lupus erythematosus (SLE) is independently linked with bipolar disorder and say the findings point to a need for greater awareness of psychiatric problems in patients with SLE. In work led by investigators at Tel Aviv University in Israel and presented at the 2017 Annual European Congress on Rheumatology (EULAR), researchers…

Accelerating Medicines Partnership Shares Its Progress on RA/Lupus Network

Lara C. Pullen, PhD  |  October 17, 2017

CHICAGO—“Why do so many drugs fail in clinical trials?” asked Michael Brenner, MD, chief of rheumatology, immunology and allergy at Brigham and Women’s Hospital in Boston. This question, previously posed by Francis Collins, MD, PhD, director of the National Institutes of Health, prompted a discussion among scientists and stakeholders in the pharmaceutical industry. The conversation…

AMP RA/Lupus Network Shares Its Progress

Lara C. Pullen, PhD  |  September 26, 2017

Researchers from the AMP RA/Lupus Network came together in June at the annual FOCIS meeting to share their progress as they perform a systematic molecular deconstruction of human diseases…

Lupus Incidence, Prevalence Differ by Race

Loraine L. Janeczko  |  September 24, 2017

NEW YORK (Reuters Health)—Racial and ethnic disparities in systemic lupus erythematosus (SLE) incidence and prevalence are considerable, according to two new studies of data from California and Manhattan. “The most important finding of the population-based California and New York registries is the confirmation of the racial and ethnic disparities of SLE, with the highest incidence…

Care Fragmentation May Increase Risk of SLE Damage & Disease Severity

Arthritis Care & Research  |  September 5, 2017

Despite the wide spread adoption of electronic health records, many systems are unable to exchange data, creating the potential for fragmented care. New research examined the effect of care fragmentation on patients with SLE in the Chicago HealthLNK Data Repository, finding that care fragmentation plays an independent role in an increased frequency of infection and disease-related morbidity damage. Researchers also found a relationship between care fragmentation, race and public insurance…

New SLE Criteria Under Development: A Joint Effort of the ACR & EULAR

Thomas R. Collins  |  August 25, 2017

MADRID—Systemic lupus erythematosus (SLE) experts in North America and Europe are working together to refine the classification system for the disease, with the goal of producing a new set of criteria that is simpler to use and more scientifically rigorous than any classification approach previously published, speakers involved with the process said at the 2017…

Comorbidities & Risk Factors for Developing SLE

Thomas R. Collins  |  August 15, 2017

MADRID—Researchers have found that systemic lupus erythematosus (SLE) is independently linked with bipolar disorder and say the findings point to a need for greater awareness of psychiatric problems in patients with SLE. In work led by investigators at Tel Aviv University in Israel and presented at the 2017 Annual European Congress on Rheumatology (EULAR), researchers…

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