NEW YORK (Reuters Health)—Helicobacter and Campylobacter species appear to play opposing roles in inflammatory bowel disease (IBD), according to a systematic review and meta-analysis. The prevalence of IBD has increased steadily in the face of falling H. pylori infection rates, suggesting a negative association, whereas some studies have suggested that some Campylobacter species are involved…
Search results for: inflammatory bowel disease
Methotrexate Increases Risk of Recurrent Nonmelanoma Skin Cancer
NEW YORK (Reuters Health)—Methotrexate appears to increase the risk of recurrent nonmelanoma skin cancer (NMSC) in patients with rheumatoid arthritis (RA), according to a retrospective study. “We have known for some time that several of the immunosuppressive agents used to treat RA and inflammatory bowel disease (IBD) are also associated with an increased risk of…
Genetic Data Suggest Dividing IBD into 3 Forms
NEW YORK (Reuters Health)—Data from a genetic association study suggest that inflammatory bowel disease (IBD) should be divided into a three-group continuum, rather than the current division between Crohn’s disease and ulcerative colitis. “The current clinical classifications of IBD, while important and useful, are a simplification of the true biological variation of this disease,” Dr….
Relapse Rates High in IBD Patients who Stop Treatment
NEW YORK (Reuters Health)—Inflammatory bowel disease (IBD) patients who achieve remission on treatment may want to go off their IBD medications. But half or more of those who do will have a relapse, according to comprehensive analysis of relevant research. “Based on the studies with extended periods of follow up, relapse rates after cessation appear…
IL-26 Plays Antimicrobial Role in Immune Response
Researchers determined IL-26 serves as a potent antimicrobial that promotes the immune sensing of both bacterial and host cell death…
ACR’s New AS & Nonradiographic Axial SpA Treatment Recommendations
ATLANTA—The American College of Rheumatology (ACR) has released new recommendations for the treatment of ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (SpA). The guideline was developed with the Spondylitis Association of America (SAA) and the Spondyloarthritis Research and Treatment Network. It summarizes recommendations for both pharmacologic and non-pharmacologic treatments, including rehabilitation, management of patients with…
Biomarkers May Help Differentiate Crohn’s From Colitis
NEW YORK (Reuters Health)—Serum biomarkers can discriminate between Crohn’s disease (CD) and ulcerative colitis (UC), according to Danish and Dutch researchers. “The biomarker assays measure neo-epitopes, which are fragments of extracellular matrix protein degradation,” Joachim Høg Mortensen, a PhD student at Nordic Bioscience in Herlev, Denmark, told Reuters Health by email. “These neo-epitopes are increasingly…
Skin Complications of Anti-TNF Therapy Common in IBD
NEW YORK (Reuters Health)—Dermatologic complications hit about one in five patients with inflammatory bowel disease (IBD) on anti-tumor necrosis factor (anti-TNF) therapy, leading to discontinuation of treatment, a French study finds. Dr. Laurent Peyrin-Biroulet, from University Hospital of Nancy, and colleagues note that dermatological complications of anti-TNF therapy are known to occur frequently in IBD…
Studies Challenge Conventional Infliximab Protocols in IBD
NEW YORK (Reuters Health)—Dose optimization of infliximab is needed much earlier in ulcerative colitis than in Crohn’s disease, a single-center retrospective study reveals. “We compared the rates of dose increases over a fairly lengthy period of time,” said Dr. Mark Silverberg, the study’s senior author from the Mount Sinai Hospital in Toronto. “Patients with ulcerative…
Increased Risk of Serious Infections During Early Anti-TNF Treatment
NEW YORK (Reuters Health)—The risk of serious infections increases in the early months of anti-TNF treatment for inflammatory bowel disease, researchers from Denmark report. “The pro-inflammatory cytokine TNF-alpha plays an important role in the immune system and therefore it is biologically plausible that TNF-alpha inhibitors may increase the risk of infections,” said Dr. Nynne Nyboe…
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