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You are here: Home / Search for "microscopic polyangiitis"

Search results for: microscopic polyangiitis

Biosimilar ABP 798 Promising for RA

February 13, 2019 • By Michele B. Kaufman, PharmD, BCGP

A clinical trial in RA patients has established the pharmacokinetic similarity of ABP 798 and rituximab…... [Read More]

Filed Under: Biologics & Biosimilars, Drug Updates

Predicting the Unpredictable – Taming the Impulse to Treat

January 17, 2019 • By Philip Seo

One of my fellows could take better care of his patients if it weren’t for the attendings getting in his way. Or so he tells me. I can hear the howls of protest already. This statement isn’t fair—it is too broad, it doesn’t fairly depict the nuances of the situation or his point of view. First,… [Read More]

Filed Under: Conditions, Rheuminations Tagged With: early arthritis, Very Early Rheumatoid Arthritis

FDA Approves Rituximab Biosimilar; Plus New Safety Data for Filgotinib in RA Patients

January 7, 2019 • By Michele B. Kaufman, PharmD, BCGP

The FDA has approved Truxima (rituximab-abbs), which is biosimilar to Rituxan (rituximab), for treating adults with CD20-positive, B-cell non-Hodgkin’s lymphoma…... [Read More]

Filed Under: Biologics & Biosimilars, DMARDs & Immunosuppressives, Drug Updates Tagged With: biosimilar, FDA, filgotinib, Rheumatoid Arthritis (RA), rituximab, rituximab-abbs, U.S. Food and Drug Administration (FDA)

AAV Remission Study: Does Rituximab or Azathioprine Work Best?

December 17, 2018 • By Thomas R. Collins

Researchers sought to identify predictors of patients with anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) who took rituximab for maintenance had a better sustained remission rate through 60 months than those taking azathioprine, according to the latest results from the maintenance of remission using rituximab in systemic ANCA-associated vasculitis (MAINRITSAN) trial, a prospective, randomized trial… [Read More]

Filed Under: Research Reviews, Vasculitis Tagged With: ANCA-Associated Vasculitis, azathioprine, MAINRITSAN, maintenance, rituximab

Rituximab Maintenance Study: Is Fixed-Schedule or Tailored Dosing Best?

December 17, 2018 • By Kurt Ullman

Rheumatologists prescribe rituximab for induction and maintenance treatment for anti-neutrophil cytoplasm antibody (ANCA) associated vasculitides (AAV). Maintenance treatment typically employs fixed-schedule dosing, but in the recent maintenance of remission using rituximab in systemic ANCA-associated vasculitis II (MAINRITSAN2) trial, researchers from the French Vasculitis Study Group examined whether individually tailored maintenance dosing might work better. “The… [Read More]

Filed Under: Research Reviews, Vasculitis Tagged With: ANCA-Associated Vasculitis, MAINRITSAN2, maintenance, rituximab

Rituximab Receives Label Update for ANCA-Associated Vasculitis

November 26, 2018 • By Michele B. Kaufman, PharmD, BCGP

The FDA has approved an update for rituximab’s label, which will include safety and efficacy information for treating ANCA-associated vasculitis…... [Read More]

Filed Under: DMARDs & Immunosuppressives, Drug Updates Tagged With: FDA, GPA, granulomatosis with polyangiitis, microscopic polyangiitis (MPA), U.S. Food and Drug Administration (FDA)

Trimethoprim-Sulfamethoxazole Prophylaxis Reduced Rituximab Infection Risk

October 18, 2018 • By Kathy Holliman

Severe infections occurred in 25% of patients with anti-neutrophil cytoplasm antibody (ANCA) associated vasculitis (AAV) who were treated with rituximab, according to results of an observational study conducted in the United Kingdom (U.K.) and Austria. Trimethoprim-sulfamethoxazole (TMP/SMX) prophylaxis, however, reduced the risk of severe infections, the investigators reported in Annals of the Rheumatic Diseases.1 Andreas… [Read More]

Filed Under: Conditions, Drug Updates, Vasculitis Tagged With: antibody-associated vasculitis, Infection, rituximab

The Promise of Molecular Medicine

September 19, 2018 • By Philip Seo

Honestly, I’m not sure why I bothered to listen. I was in my kitchen, early on a Saturday morning, with the radio keeping me company. It started with the news and the usual litany of tragedies, both major and minor, that comprise such programs. The news gradually faded into other programming, which I can no… [Read More]

Filed Under: Rheuminations Tagged With: Genes, genetics

Cutaneous Lupus Tied to Risk for Coexisting Autoimmune Conditions

May 10, 2018 • By Marilynn Larkin

NEW YORK (Reuters Health)—Patients with cutaneous lupus erythematosus (CLE) should be monitored closely for other autoimmune conditions, researchers suggest. Dr. Benjamin Chong, Dr. Linda Hynan and Elaine Kunzler of the University of Texas Southwestern Medical Center in Dallas analyzed data from 129 adults in the UTSW Cutaneous Lupus Registry (mean age, 49; 79% women). Individuals… [Read More]

Filed Under: Conditions Tagged With: coexisting autoimmune conditions, cutaneous lupus erythematosus (CLE), UTSW Cutaneous Lupus Registry

Kussmaul, Meier & Polyarteritis Nodosa

April 26, 2018 • By Ruth Jessen Hickman, MD

In 1866, Adolf Kussmaul, an internist, and Rudolf Maier, a pathologist, published the classic characterization of what eventually became known as polyarteritis nodosa.1 It was the first scientific clinical characterization of a noninfectious vasculitis. As such, it became a paradigmatic point of contrast to other types of vasculitides that were later described. Their description also… [Read More]

Filed Under: Vasculitis Tagged With: History, Lost & Found, polyarteritis nodosa, scientific method, Vasculitis

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