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Articles tagged with "microRNA"

Standing on a Hidden Burden: The Oft-Overlooked Problem of Foot and Ankle Osteoarthritis

Regeneration: RheumMadness 2022 Axolotl Limbs Scouting Report

Wake Forest School of Medicine Rheumatology Fellowship Program: Khiem Vu, MD; Alyssa Strazanac, MD; John Herion, DO; & Rami Diab, MD  |  February 14, 2022

Daily living, such as walking, jumping and going up stairs, can be difficult for patients with osteoarthritis (OA). Research on the regenerative limbs of the axolotl and the human ankle provides insights into the potential of this process in humans and its implications for hip, knee and ankle OA.

Circulating MicroRNA Provides Clues to Class IV Lupus Nephritis

Lara C. Pullen, PhD  |  January 29, 2018

A recent study has shed light on the role of circulating microRNAs (miRNAs) in SLE pathogenesis. In particular, patients with lupus nephritis have an abundance of 24 miRNAs, many of which play a role in regulatory feedback loops…

MicroRNAs Provide Insight into Bone Metabolism

Lara C. Pullen, PhD  |  May 1, 2017

A recent study examined the functional variants within microRNAs that affect bone metabolism and possibly bone disorders. Researchers found overexpression of microRNAs may contribute to the osteoporotic phenotype, and the gene targets associated with two specific osteoblast-expressed microRNAs may be critical in osteoporosis…

MicroRNA Mediates Gene Regulation That Underlies JIA Pathology

Lara C. Pullen, PhD  |  July 25, 2016

Through the use of large-scale transcriptome analysis, researchers have gained insight into the role of innate immunity in juvenile idiopathic arthritis (JIA) pathology. Specifically, transcriptomes of neutrophils in chronic inflammatory states demonstrate extensive network rewiring caused by microRNA, suggesting a role for alternative splicing in JIA pathogenesis…

MicroRNA-Based Therapeutics Hold Promise Against Lupus, Other Rheumatic Diseases Note Experts at the ACR/ARHP’s 2013 Annual Meeting

Susan Bernstein  |  April 2, 2014

Studies suggest deregulation, dysfunction of miRNAs in human, mice models of lupus may be future targets for gene therapy

EULAR 2012: MicroRNAs’ Role in Rheumatic Diseases Coming into Sharper Focus

Thomas R. Collins  |  September 5, 2012

MicroRNAs are poised to play a big role in the future understanding and treatment of rheumatoid arthritis.

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