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Search results for: macrophage

Editor's Pick

Weathering the Cytokine Storm: Macrophage Activation Syndrome in Adults & Children

Katie Robinson  |  December 18, 2024

Peter Nigrovic, MD, provides a practical guide to the diagnosis & treatment of macrophage activation syndrome (MAS) in children & adults.

Filed under:ConditionsOther Rheumatic ConditionsPediatric Conditions Tagged with:Arthritis & RheumatologyEditor's PickImmunologymacrophage activation syndromeMAS

How to Effectively Diagnose & Treat Macrophage Activation Syndrome

Vanessa Caceres  |  May 30, 2024

“As a resident, [I] felt pretty terrible when [we had] a very sick child and the teams [couldn’t] agree on what to do,” said Lauren Henderson, MD, MMS, on an episode of ACR on Air. She discussed the importance of collaboration across specialties in the identification and treatment of macrophage activation syndrome (MAS).

Filed under:ConditionsPediatric ConditionsVasculitis Tagged with:hemophagocytic lymphohistiocytosis (HLH)macrophage activation syndromeMASpatient care

New Options Emerge for Treating Macrophage Activation Syndrome

Mike Fillon  |  March 19, 2020

ATLANTA—Macrophage activation syndrome (MAS), a subset of hemophagocytic lymphohistiocytosis (HLH) disease, can be a fatal result of rheumatic disease. But there’s good news: New therapeutic options for refractory MAS targeting individual cytokines are emerging. At the 2019 ACR/ARP Annual Meeting, possible therapeutic options were presented during a pediatric-focused clinical and translational research track, Therapeutic Approaches…

Filed under:Conditions Tagged with:2019 ACR/ARP Annual MeetingIL-1macrophage activation syndrome

Alterations in Macrophage Activation May Signal a Lupus Flare

Lara C. Pullen, PhD  |  February 11, 2019

New data suggest myeloid cells in SLE patients skew B and T cell activation status toward the M1 proinflammatory phenotype, thereby directing SLE flares and remission…

Filed under:ConditionsSystemic Lupus Erythematosus Tagged with:genemyeloid cellsSLEsystemic lupus erythematosus (SLE)

Research Links Macrophages with Pathogenesis of Inflammation, Fibrosis

Thomas R. Collins  |  October 17, 2017

MADRID—Research into pharmacodynamic biomarkers has shown that macrophages may have an important role in the pathogenesis of several diseases, including systemic sclerosis, an expert said at the 2017 Annual European Congress on Rheumatology (EULAR). The findings were discussed in a session that also covered how an understanding of M1 macrophages’ role in fibrosis has evolved…

Filed under:ConditionsMeeting ReportsOther Rheumatic ConditionsResearch Rheum Tagged with:BiomarkersEULARfibrosisinflammationmacrophagemeeting reportsPathogenesispharmacodynamicpredictResearchRheumatic Diseaserheumatologyskin diseaseskin scoreSystemic sclerosis

The Role of Macrophages in Inflammation & Fibrosis: Macrophages May Predict Progressive Skin Disease

Thomas R. Collins  |  August 15, 2017

MADRID—Research into pharmacodynamic biomarkers has shown that macrophages may have an important role in the pathogenesis of several diseases, including systemic sclerosis, an expert said at the 2017 Annual European Congress on Rheumatology (EULAR). The findings were discussed in a session that also covered how an understanding of M1 macrophages’ role in fibrosis has evolved…

Filed under:ConditionsEULAR/OtherMeeting ReportsSystemic Sclerosis Tagged with:EULARfibrosisInflammasomemacrophagesskinskin diseasetocilizumab

New Criteria Released for Macrophage Activation Syndrome in Juvenile Idiopathic Arthritis

Susan Bernstein  |  August 10, 2016

Although most systemic juvenile idiopathic arthritis patients don’t develop macrophage activation syndrome (MAS), the approximately 10% who do have this serious complication can experience widespread, massive inflammation, debilitating symptoms and even death. To improve understanding of MAS among physicians and advance efforts to develop effective therapies to treat it, a panel of 28 international pediatric…

Filed under:ConditionsResearch Rheum Tagged with:criteriaDiagnosisJuvenile idiopathic arthritismacrophage activation syndromepatient careResearchrheumatologistrheumatologyTreatment

2015 ACR/ARHP Annual Meeting: Macrophage Polarization and Its Role in Inflammatory Disease

Susan Bernstein  |  April 14, 2016

SAN FRANCISCO—To unravel how out-of-control inflammation begins in rheumatoid arthritis and other diseases, one target for immunologists is the macrophage. Researchers discussed macrophage activation and other key drivers of inflammation at the 2015 ACR/ARHP Annual Meeting on Nov. 7. How macrophages behave when recognizing damage-associated molecular pathways (DAMPs) tells us more about why some inflammation doesn’t…

Filed under:ConditionsMeeting ReportsOther Rheumatic ConditionsResearch Rheum Tagged with:2015 ACR/ARHP Annual MeetingAmerican College of Rheumatology (ACR)DiseaseinflammationmacrophagepolarizationResearchRheumatoid arthritis

Researchers Find the Switch that Underlies Macrophage Metabolism

Lara C. Pullen, PhD  |  March 28, 2016

During pro-inflammatory stimulation, a recent study found HIF1α—not Myc—is required for the regulation of glycolysis in macrophages. Researchers examined macrophages and the distinct transcriptional programs engaged in response to mitogenic and pro-inflammatory stimulation…

Filed under:ConditionsResearch Rheum Tagged with:inflammationmacrophagesmetabolism

2014 ACR/ARHP Annual Meeting: Macrophage Activation Syndrome

Mary Beth Nierengarten  |  April 1, 2015

The pathogenesis of and new classification criteria for MAS

Filed under:ConditionsOther Rheumatic ConditionsResearch Rheum Tagged with:ACR/ARHP Annual Meetingcytokine storm syndromemacrophage activation syndromeNierengartenResearchRheumatic Disease

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