NEW YORK (Reuters Health)—The route of iron replacement therapy alters the gut microbiome and metabolomics in patients with inflammatory bowel disease (IBD), but the route is unrelated to disease activity and quality of life, according to a new study. “Crohn’s disease patients are extremely fragile to disturbances and one might speculate about consequences in long-term…
Market Turmoil Drives Small Biotechs to Big Pharma
(Reuters)—Numerous small biotechnology companies have been all but shut out of the capital markets, leaving many with no choice but to consider a sale to larger peers. The Nasdaq Biotech Index is down nearly 30% since September, when Democratic presidential candidate Hillary Clinton criticized drug companies’ “price gouging” on Twitter and sparked concerns about a…
Pfizer Unit to Pay $784.6 Million in Medicaid Rebate Settlement
(Reuters)—Pfizer Inc. said its Wyeth unit has agreed to pay $784.6 million to settle cases related to the calculation of Medicaid rebates for a gastric drug between 2001 and 2006. The claims alleged that Wyeth’s calculation of rebates for its proton pump inhibitor Protonix (pantoprazole) violated the Federal Civil False Claims Act and other laws…
FDA Update: Infliximab Biosimilar Garners Support & Fibromyalgia Drug Receives Fast Track
Recently, an FDA committee announced support for the approval of CT-P13, an infliximab biosimilar. The FDA has also fast tracked the development of a fibromyalgia treatment designed for multiple symptoms…
Study Targets Osteoclast Receptor to Inhibit Osteoclastogenesis
The results of a new study examined the human osteoclast-associated receptor may aid in the development of therapeutic matrikines to control aberrant osteoclastogenesis in some autoimmune diseases…
Fungal Microbiota Dysbiosis Seen in Inflammatory Bowel Disease
NEW YORK (Reuters Health)—Patients with inflammatory bowel disease (IBD) show imbalance in their fungal intestinal microbiota, according to new findings. “The fungal microbiota is a new actor to take into account in the pathogenesis of IBD and potentially in other diseases,” Dr. Harry Sokol of Hospital Saint-Antoine in Paris, an author of the new study,…
Tofacitinib Decreases Inflammation in Early RA
A recent study used MRI to show that tofacitinib reduces inflammation and inhibition of the progression of structural damage in adults with early RA…
Textile Workers at Higher Risk for Rheumatoid Arthritis
(Reuters Health)—Breathing textile dust on the job is linked to an almost tripled risk of developing rheumatoid arthritis (RA), a Malaysian study suggests. While smoking is a known risk factor for RA, the findings add to evidence suggesting that environmental factors could trigger RA in some people, the researchers note in their report in Annals…
How Technology Can Benefit Rheumatology Practices
Electronic health records, mobile apps, telemedicine, patient portals—new technologies offer rheumatologists more efficiency and patients greater knowledge. Here are a few ways these technologies can aid a practice…
Gut-on-a-Chip Provides Insight into Microbiome & Intestinal Inflammation
Researchers have created a microdevice with Caco-2 intestinal epithelial cells to aid in studying the human gut microbiome’s role in homeostasis, immune modulation and pathology. Using this gut-on-a-chip, researchers were able to examine in detail the processes they think result in chronic intestinal inflammation…
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