NEW YORK (Reuters Health)—Patients with suspected large-vessel vasculitis (LVV) should undergo early imaging, the European League Against Rheumatism (EULAR) advises in a new report presenting a dozen evidence-based recommendations for the use of imaging in primary LVV. Ultrasound should be the first choice for giant-cell arteritis (GCA), while MRI should take precedence for Takayasu arteritis…
Mouse Model Suggests Regulatory T Cells Play Important Role in Sjögren’s Syndrome Pathophysiology
Recent research investigated the progression and characteristics of Sjögren’s syndrome using mice engineered to lack special genome organizing AT-rich sequence binding protein-1 (SATB1). These mice proved to be a novel model for Sjögren’s syndrome and revealed T cell-dominant immune cell infiltration of the salivary glands. Over time, the frequency of B cells gradually increased, as well as the levels of anti-SSA and anti-SSB antibodies…
Upadacitinib Receives Breakthrough Designation, Abatacept Use Expands in Australia & More
The FDA has designated upadacitinib a breakthrough therapy to treat adults with moderate to severe atopic dermatitis…
Service Dogs Aid RA Patients with Mobility, Chores, Companionship & More
Patients with severe RA can struggle with walking, getting dressed, carrying items and more, all of which can negatively affect their quality of life. But according to Bharat Kumar, MD, service dogs can help RA patients by providing both physical and emotional support, aiding patient mobility and quality of life…
Arthritis More Common Than Previously Thought
Arthritis prevalence in the U.S. population has been substantially underestimated, especially among adults younger than 65.
Circulating MicroRNA Provides Clues to Class IV Lupus Nephritis
A recent study has shed light on the role of circulating microRNAs (miRNAs) in SLE pathogenesis. In particular, patients with lupus nephritis have an abundance of 24 miRNAs, many of which play a role in regulatory feedback loops…
Higher Fracture Risk in Patients with Polymyalgia Rheumatica, Giant-Cell Arteritis
NEW YORK (Reuters Health)—Patients with polymyalgia rheumatica (PMR) and giant-cell arteritis (GCA) have similarly increased risks of fracture, compared with the general population, researchers have found. “It is of surprise that patients with GCA have a similar fracture risk to those with PMR,” Dr. Zoe Paskins from Keele University, in Staffordshire, told Reuters Health by…
Synthetic DMARDs May Blunt Pneumococcal Vaccine Response in Systemic Sclerosis
NEW YORK (Reuters Health)—Pneumococcal vaccination yields a satisfactory antibody response in patients with systemic sclerosis (SSc), but synthetic disease-modifying antirheumatic drugs (DMARDs) might reduce the vaccine response in these individuals, according to a report from Sweden. The prospective study, published online Jan. 8 in Rheumatology, evaluated the response to either pneumococcal conjugate vaccine (PCV13) or…
Sleep Tips for RA Patients & Rheumatologists
A lack of quality sleep may exacerbate depression and pain in patients with rheumatoid arthritis, according to Michael R. Irwin, MD. Here are some tips for rheumatologists on how to discuss sleep with patients and help patients reduce sleep disturbance…
Potential Therapeutic Target for SpA
Innate lymphoid cells (ILCs) in the joints of patients may drive the pathology of spondyloarthritis through the production of granulocyte colony-stimulating factor (GM-CSF). A recent study found that both GM-CSF-producing CD4 T cells and the GM-CSF+ Th17 cells expressed high levels of GPR65—indicating that both GM-CSF and GPR65 may be therapeutic targets for spondyloarthritis…
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