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Search results for: anti-phospholipid antibodies

‘Nothing but NET[osis]’: RheumMadness 2022 Anti-NET Antibodies Scouting Report

The UNC Rheumatology Fellowship Program: Leah Bettner, MD; Shruti Chandramouli, MD; Christopher Overton, MD; Astia Allenzara, MD; Michael Cunningham, MD; & Luis Palomino, MD  |  February 8, 2022

Neutrophil extracellular traps (NETs) contribute to the pathogenesis of multiple autoimmune diseases. And research has shown that patients with antiphospholipid syndrome (APS) have higher levels of circulating anti-NET antibodies than healthy controls, indicating a potential biomarker.

Filed under:ConditionsOther Rheumatic ConditionsResearch Rheum Tagged with:anti-NET antibodiesAntiphospholipid Antibody Syndrome (APS)APScellsNETosisneutrophil extracellular trapsRheumMadness

Case Report: Lupus Nephritis, or a Mimic?

Matthew J. Mandell, DO, FACP, Yishui Chen, MD, Prerna Rastogi, MD, PhD, & Rebecca Tuetken, MD, PhD  |  May 31, 2025

Syphilis, an ancient disease caused by the spirochete Treponema pallidum, has been historically referred to as the great mimicker given its heterogenous presentation. Both systemic lupus erythematosus (SLE) and syphilis can have multi-systemic involvement. Both parvovirus B19 and syphilis have been reported to cause histologic features similar to those seen in lupus nephritis. We present…

Filed under:ConditionsSystemic Lupus Erythematosus Tagged with:case reportLupus nephritis supplementparvovirus B19syphilis

Case Report: Lupus Nephritis or a Mimic?

Matthew J. Mandell, DO, Yishui Chen, MD, Prerna Rastogi, MD, PhD, & Rebecca Tuetken, MD, PhD  |  November 10, 2022

Syphilis, an ancient disease caused by the spirochete Treponema pallidum, has been historically referred to as the great mimicker given its heterogenous presentation. Both systemic lupus erythematosus (SLE) and syphilis can have multi-systemic involve­ment. Both parvovirus B19 and syphilis have been reported to cause histologic features similar to those seen in lupus nephritis.  We present…

Filed under:ConditionsSystemic Lupus Erythematosus Tagged with:case reportFellowsFellows ForumFellows-in-TrainingLupus nephritisparvovirus B19syphilis

Pregnancy Outcomes in Women with Idiopathic Inflammatory Myositis

Lara C. Pullen, PhD  |  April 8, 2019

New data from India suggest women with idiopathic inflammatory myositis are at increased risk of poor fetal outcomes and spontaneous abortions. In the study, researchers found these women had worse obstetric outcomes and increased risk of fetal complications…

Filed under:ConditionsMyositis Tagged with:birthidiopathic inflammatory myositisOutcomespregnancypregnant women

Lupus Patient Develops Miller Fisher Variant of Guillain-Barré Syndrome

Sedrick Bradley, MD, & Nirupa J. Patel, MD  |  October 18, 2018

Systemic lupus erythematosus (SLE) is a heterogeneous, auto­immune, inflammatory, connective tissue disease affecting multiple organs. Neither central nervous system nor peripheral nervous systems are spared. The neurologic system is involved in a wide range of 10–80% of patients with SLE. Peripheral neuropathy, such as Guillain-Barré syndrome (GBS) and its variants, can occur in neurologic complications…

Filed under:ConditionsSystemic Lupus Erythematosus Tagged with:areflexiaataxiaGuillain-Barré SyndromeMiller Fisher Syndromeophthalmoplegia

APS: What Rheumatologists Should Know about Hughes Syndrome

Graham R.V. Hughes, MD, FRCP  |  February 17, 2016

The problem that dogs the work of all of those treating patients with antiphospholipid syndrome (APS) is the apparent lack of knowledge of the syndrome, both by the general public, as well as by swaths of the medical fraternity. Perhaps it was ever thus—a syndrome less than 40 years old could be described as new,…

Filed under:ConditionsOther Rheumatic Conditions Tagged with:Antiphospholipid Antibody Syndrome (APS)brainClinicalDiagnosisHughes Syndromejointpatient carepregnancyrheumatologiststrokesymptomthrombosis

Rheumatology Case Report: Chondromyxoid Fibroma of the Sternum

Rajaie Namas, MD, Reshma Khan, MD, & Bernard Rubin, DO  |  February 16, 2016

A 47-year-old Caucasian woman presented to the rheumatology clinic with a one-year history of pain and swelling involving the wrists, hands, ankles and feet that progressively worsened. Her symptoms included generalized fatigue, morning stiffness in the hands and lower back lasting more than an hour, Raynaud’s phenomena (triphasic), photosensitivity, tightening of the skin of the…

Filed under:ConditionsSystemic Sclerosis Tagged with:Autoimmune diseasechondromyxoid fibromaClinicalDiagnosisoutcomepatient carerheumatologyScleroderma

A Young Disease: A Holistic Approach to the Treatment of Antiphospholipid Syndrome

Samantha C. Shapiro, MD  |  September 8, 2022

Although progress has been made in recent years, rheumatologists still have a lot of questions regarding best management practices for antiphospholipid syndrome (APS). During a session of EULAR 2022, Ricard Cervera, MD, PhD, described a holistic approach.

Filed under:ConditionsMeeting ReportsOther Rheumatic Conditions Tagged with:Antiphospholipid Antibody Syndrome (APS)cardiovascularcatastrophic antiphospholipid syndromeEULARGlucocorticoidspatient care

Promote Pregnancy Wellness: Data Can Help Guide Pregnancy Management in Lupus

Thomas R. Collins  |  September 10, 2018

AMSTERDAM—Clinicians who are counseling women with systemic lupus erythematosus (SLE) have the benefit of an array of new insights into factors linked with increased risk of pregnancy loss, how SLE therapies affect pregnancy and data on outcomes of children born to mothers with SLE, an expert said in a session at EULAR: the Annual European…

Filed under:ConditionsSystemic Lupus Erythematosus Tagged with:HYDROXYCHLOROQUINELupus nephritispregnancypregnant womensystemic lupus erythematosus (SLE)

Case Report: Refractory Calciphylaxis in Lupus

Joey Kim, MD, Navneet Kaur, MD, Phillip Zhang, MD, & Irene Blanco, MD, MS  |  May 17, 2018

Calciphylaxis is a poorly understood and life-threatening ischemic vasculopathy characterized by calcification of the small- and medium-size arteries in the skin, subcutaneous tissue and internal organs, which leads to thrombosis, tissue necrosis and painful skin ulcerations that won’t heal. The disease has a 50–80% mortality rate. Although affected patients typically have end-stage renal disease (ESRD)…

Filed under:Systemic Lupus Erythematosus Tagged with:calciphylaxisconnective tissue diseaseSystemic lupus erythematosus

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