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You are here: Home / Search for "dermatomyositis"

Search results for: dermatomyositis

Anti-SAE Identifies a Subtype of Dermatomyositis

November 22, 2021 • By Lara C. Pullen, PhD

Albayda et al. describes a North American cohort of patients with dermatomyositis, reporting that small ubiquitin-like modifier activating enzyme (SAE) autoantibodies are clearly associated with this clinical disease. Patients with this clinical phenotype most commonly present with a rash first, followed by muscle involvement.... [Read More]

Filed Under: Conditions Tagged With: dermatomyositis, dermatomyositis (DM), phenotype, small ubiquitin-like modifier activating enzyme (SAE)

FDA Approves IVIG to Treat Adults with Dermatomyositis

August 17, 2021 • By Michele B. Kaufman, PharmD, BCGP

In July, the FDA approved the use of Octagam 10%, an intravenous immunoglobulin solution, to treat dermatomyositis in adults after an international study demonstrated the treatment’s safety and efficacy.... [Read More]

Filed Under: Drug Updates Tagged With: dermatomyositis, dermatomyositis (DM), FDA, FDA approval, immunoglobulin, intravenous human immunoglobulin, Octagam 10%, U.S. Food and Drug Administration (FDA)

Updates in Juvenile Dermatomyositis: Pathogenesis & Patient Care

July 17, 2021 • By Jason Liebowitz, MD

Experts provided an update on juvenile dermatomyositis, discussing patient care, treatment options and the pathogenesis of disease.... [Read More]

Filed Under: Conditions, Meeting Reports Tagged With: juvenile dermatomyositis, Pathogenesis, Pediatric Rheumatology, Pediatric Rheumatology Symposium, PRSYM

Polymyositis-Dermatomyositis Tied to Arrhythmias in Young, Middle-Aged Adults

June 22, 2021 • By Lisa Rapaport

(Reuters Health)—Young and middle-aged adults with polymyositis-dermatomyositis are more likely to have arrhythmias in general, and supraventricular arrhythmias in particular, than matched controls without these rare rheumatic conditions, a U.S. study suggests.1 Researchers examined retrospective data on adults hospitalized between 2016 and 2018, including 32,085 patients with polymyositis-dermatomyositis and 320,850 age-matched controls. Overall, both women… [Read More]

Filed Under: Conditions Tagged With: arrhythmia, dermatomyositis, heart, polymyositis

Case Report: A Rare But Severe Complication of Dermatomyositis

May 13, 2021 • By Akrithi Udupa, MD, Paul McIntosh, MD, Thomas J. Cummings, MD, & Lisa Criscione-Schreiber, MD, Med

Dermatomyositis is an uncommon autoimmune condition involving skeletal muscle characterized by subacute onset of progressive weakness, intramuscular inflammatory infiltrates and the presence of myositis-specific autoantibodies.1 Immune-mediated myopathies may exert some pathogenic effects on the muscle tissue by targeting the microvasculature.1 Capillary inflammation, fragility and loss may contribute to heightened bleeding events in these patients. Here,… [Read More]

Filed Under: Conditions Tagged With: case report, dermatomyositis (DM), hemorrhagic dermatomyositis

Case Report: Mycosis Fungoides in Dermatomyositis

March 15, 2021 • By Barrett Ford, MD, Chandana Shilpa Ravipati, DO, & Nirupa Patel, MD

Dermatomyositis (DM) is an idiopathic inflammatory myopathy involving proximal muscle weakness and skin rash. An associated increased risk of malignancy is well established.1 The most frequent malignancies are related to the ovary, endometrium, lung, gastrointestinal tract, prostate, breast and lymphatics.2 On rare occasions, DM has been reported with certain types of non-Hodgkin’s lymphoma, specifically cutaneous… [Read More]

Filed Under: Conditions Tagged With: case report, dermatomyositis (DM), mycosis fungoides

Case Report: A Patient with Clinically Amyotrophic Dermatomyositis & Associated ILD & RA Overlap

May 15, 2020 • By Vania Lin, MD, MPH, & Leah Krull, MD

The initial physical examination was significant for a nonblanching, papular rash along the palmar aspects of the hands and digits, periungual erythema, and edema and tenderness of the proximal and distal interphalangeal joints of the hands.

Clinically amyotrophic dermatomyositis (CADM), a subset of dermatomyositis (DM), is a rare autoimmune disease characterized by typical DM cutaneous findings (e.g., heliotrope rash, Gottron papules, Gottron sign) without evidence of myositis.1 The incidence of DM and CADM is approximately 9.63 per 1 million people and 2.08 per 1 million people, respectively.2 The association with development… [Read More]

Filed Under: Conditions, Rheumatoid Arthritis Tagged With: Clinically Amyotrophic Dermatomyositis (CADM), combination therapy, interstitial lung disease (ILD)

A Combined Immunosuppressive Regimen for ILD MDA5-Positive Dermatomyositis

February 27, 2020 • By Arthritis & Rheumatology

Interstitial lung disease accompanied by anti-melanoma differentiation-associated gene 5 positive dermatomyositis is often rapidly progressive and associated with poor prognosis. In this study, a combined immunosuppressive regimen of high-dose glucocorticoids, tacrolimus and intravenous cyclophosphamide proved more effective than treatment with high-dose glucocorticoids and stepwise addition of an immunosuppressant in a historical control group.... [Read More]

Filed Under: Conditions Tagged With: Arthritis & Rheumatology, dermatomyositis (DM), ILD, interstitial lung disease (ILD)

Tofacitinib Shows Early Potential for Treating Dermatomyositis

January 16, 2019 • By Carina Stanton

A proof-of-concept study including 10 patients treated for dermatomyositis with tofacitinib, an FDA-approved drug for RA and psoriatic arthritis, shows strong clinical efficacy…... [Read More]

Filed Under: Conditions

European Group Offers Guidance on Managing Juvenile Dermatomyositis

August 30, 2016 • By Reuters Staff

NEW YORK (Reuters Health)—A European working group has formulated consensus-based recommendations for the diagnosis and treatment of juvenile dermatomyositis (JDM) with the goal of producing a “standard of care” for patients with JDM throughout Europe. The group is part of a European initiative called SHARE [Single Hub and Access point for pediatric Rheumatology in Europe]… [Read More]

Filed Under: Conditions, Systemic Inflammatory Syndromes Tagged With: Europe, Guidelines, juvenile dermatomyositis, Pediatric, skin

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