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Search results for: glucocorticoids

Glucocorticoids Increase Infections, Mortality

Arthritis & Rheumatology  |  August 19, 2024

Figueroa-Parra et al. set out to evaluate the effect of glucocorticoid regimens on renal response, infections and mortality rates among patients with lupus nephritis (LN). The researchers analyzed the control arms of randomized clinical trials and found a higher exposure to glucocorticoids during the initial treatment of LN was associated with better renal outcomes, at the cost of increased infections and mortality.

Filed under:Biologics/DMARDsConditions Tagged with:Arthritis & RheumatologyGlucocorticoidsLupus nephritismortalityRenal

3 AC&R Study Summaries: Prescribing Patterns, PMR & Glucocorticoids, & Infection Screening

Arthritis Care & Research  |  February 9, 2024

A Shift in Prescribing Patterns Safety issues prompt discontinuation of tofacitinib By Stephanie Song, MD, & Joshua F. Baker, MD, MSCE Why was this study done? The ORAL Surveillance study highlighted risks of cardiac events, thromboembolism (VTE) and malignancy associated with use of Janus kinase inhibitors (JAKi). We sought to determine the impact of safety…

Filed under:Biologics/DMARDsConditionsDrug UpdatesOther Rheumatic ConditionsResearch ReviewsResearch RheumRheumatoid Arthritis Tagged with:GlucocorticoidsInfectionJAK inhibitorsPolymyalgia RheumaticaReading Rheumsteroid-sparing therapiesTofacitinib

Reduced-Dose Glucocorticoids for GPA & Microscopic Polyangiitis

Arthritis & Rheumatology  |  December 1, 2023

SAN DIEGO—In a study titled Real-Life Use of the PEXIVAS Reduced-dose Glucocorticoid Regimen in Granulomatosis with Polyangiitis and Microscopic Polyangiitis, Nagle et al. evaluated the efficacy and safety of the reduced-dose glucocorticoid regimen in a real-world setting. Background/Purpose Glucocorticoids (GCs) in combination with rituximab (RTX) or cyclophosphamide are the cornerstone of treatment for patients with…

Filed under:ACR ConvergenceConditionsMeeting ReportsVasculitis Tagged with:AAVAAV FocusRheumACR Convergence 2023Arthritis & RheumatologyCorticosteroidsgranulamatosis with polyangiitismicroscopic polyangiitis (MPA)Research

Glucocorticoids in RA

David S. Pisetsky, MD, PhD  |  November 7, 2023

The historical & continuing roles of glucocorticoids in the treatment of RA are discussed. 

Filed under:Education & TrainingRheumatoid Arthritis Tagged with:GlucocorticoidsRA Resource CenterRheumatoid Arthritis (RA)

Glucocorticoids May Decrease White Matter Integrity & Change Gray Matter Volume

Samantha C. Shapiro, MD  |  February 27, 2023

Van der Meulen et al. found the use of both systemic and inhaled glucocorticoids is associated with changes in several brain imaging parameters, including decreased white matter integrity and gray matter volume. Study patients also reported more depressive symptoms and tiredness than controls.

Filed under:ConditionsDrug Updates Tagged with:brainDepressionGlucocorticoidsinhaled corticosteroidsside effectSteroids

Clinical Challenges in SLE: Glucocorticoids—How Much Is Too Much?

Samantha C. Shapiro, MD  |  July 22, 2022

Glucocorticoids remain a prominent part of care for many patients with SLE but can have toxic side effects; this EULAR 2022 session discussed one institution’s approach to lower the dosage.

Filed under:ConditionsMeeting ReportsSystemic Lupus Erythematosus Tagged with:GlucocorticoidsHCQHydroxychloroquine (HCQ)prednisoneSLEsystemic lupus erythematosus (SLE)

How Do Reduced-Dose Glucocorticoids Plus Rituximab Affect ANCA-Associated Vasculitis?

Lara C. Pullen, PhD  |  October 13, 2021

Furuta et al. evaluated the benefits of reducing glucocorticoid doses during remission induction for patients with ANCA-associated vasculitis. The researchers found a reduced-dose-glucocorticoid-plus-rituximab regimen was noninferior to a regimen of high-dose glucocorticoids plus rituximab in these patients.

Filed under:ConditionsVasculitis Tagged with:ANCA-Associated VasculitisGlucocorticoidsRemissionrituximab

Bisphosphonates May Limit Fracture Risk in Users of Oral Glucocorticoids

Reuters Staff  |  November 8, 2017

NEW YORK (Reuters Health)—Early oral bisphosphonate use is associated with a lower risk of fractures among oral-glucocorticoid users, researchers from Canada report. Bisphosphonates are commonly used for glucocorticoid-induced osteoporosis, but their efficacy has been established only in primary osteoporosis, where the mechanism of action of bone loss differs from that seen with glucocorticoid use. Dr….

Filed under:ConditionsDrug UpdatesOsteoarthritis and Bone Disorders Tagged with:bisphosphonatesCanada reportearly oral bisphosphonate usefracture riskFracturesGlucocorticoid-Induced Osteoporosisoral-glucocorticoid usersOsteoporosis

New Assay Aids In Evaluating Metabolic Effects of Glucocorticoids

Lara C. Pullen, PhD  |  October 31, 2014

Test measures efficacy of compounds for treating arthritis and their effect on glucose kinetics

Filed under:Drug UpdatesResearch Rheum Tagged with:ArthritisGlucocorticoidsglucosemetabolismTestTreatment

Glucocorticoids a Fracture Risk at Any Dose

Kathy Holliman  |  March 18, 2011

Updated recommendations advocate doing more to determine fracture risk and the need for preventive therapy

Filed under:ConditionsDrug UpdatesOsteoarthritis and Bone Disorders Tagged with:boneFracturesGlucocorticoid-Induced OsteoporosisGlucocorticoidsGuidelinesOsteoporosispatient careSteroids

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