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Search results for: immune checkpoint inhibitors

Alpha Tauri 3D Graphics / shutterstock.com

Rheumatic Complications from Immune Checkpoint Inhibitors

Nilasha Ghosh, MD, MS, & Anne R. Bass, MD  |  December 16, 2021

Immune checkpoint inhibitors (ICIs), such as anti-programmed cell-death 1/programmed death-ligand 1 (anti-PD-1/PD-L1) or anti-CTL-associated protein (anti-CTLA-4), have dramatically changed the treatment of advanced cancers over the past decade. ICIs block T cell inhibition, thus increasing the anti-tumor immune response. ICIs are used not only for metastatic cancer, but also as adjuvant treatment for some stage…

Filed under:Conditions Tagged with:immune checkpoint inhibitor (ICI)immune-related adverse events

Reassuring Data on Immune Checkpoint Inhibitors in Autoimmune Disease

Reuters Staff  |  February 22, 2021

NEW YORK (Reuters Health)—Patients with preexisting autoimmune disease (AIDs) are not at increased risk for immune-related adverse events from immune checkpoint inhibitor (ICI) therapy, although these adverse events may be more likely in patients with inflammatory bowel disease (IBD), new research indicates. “Therefore, we encourage physicians not to withhold ICI in most common AIDs. However,…

Filed under:Drug Updates Tagged with:adverse eventsAutoimmune diseaseimmune checkpoint inhibitor (ICI)immune-related adverse events

ACR Convergence graphic

Check It Out: Understanding Immune-Related Adverse Events from Immune Checkpoint Inhibitors

Jason Liebowitz, MD, FACR  |  December 4, 2020

Immune checkpoint inhibitors effectively treat malignancy in ways that were not possible just a few years ago, but immune-related adverse events are a potential side effect.

Filed under:ACR ConvergenceDrug UpdatesMeeting Reports Tagged with:ACR Convergence 2020immune checkpoint inhibitor (ICI)Immune checkpoint inhibitorsimmunotherapy

Immune Checkpoint Inhibitors & Immune-Related Adverse Events

Priya Chokshi, MD, Roberta Seidman, MD, Noah Levit, PhD, MD, & Steven E. Carsons, MD  |  September 20, 2018

Immune checkpoint inhibitors (ICIs) are at the forefront of advances in cancer therapy and have shown promising results for progression-free survival. Checkpoint signaling pathways, such as cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1), normally regulate the immune response to promote self-tolerance and prevent tissue damage and inflammation. PD-1 is a…

Filed under:ConditionsDrug UpdatesMyositisOther Rheumatic Conditions Tagged with:immune-related adverse eventsirAEsmyositisnivolumab

Study Assesses Immune Checkpoint Inhibitors Safety in Rheumatic Disease

Kurt Ullman  |  May 18, 2018

Since they were first introduced in 2011, immune checkpoint inhibitors (ICIs) have become an important treatment for an expanding list of advanced cancers. Some concerns have been raised around the mechanism of action of these immunotherapy agents, making their use in rheumatic diseases (RD) problematical. An article in the March 2018 issue of Arthritis &…

Filed under:ConditionsDrug UpdatesRheumatoid Arthritis Tagged with:immune checkpoint inhibitor (ICI)

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The Immune Checkpoint Inhibitors Unleashed to Fight Cancer

Dana Direnzo, MD, Ami A. Shah, MD, MHS, Clifton O. Bingham III, MD, & Laura C. Cappelli, MD, MHS  |  May 17, 2017

A 53-year-old female presented to the clinic for severe polyarticular joint pain and was found to have a seronegative inflammatory arthritis. Six months before, she had completed 10 months of treatment for stage IV metastatic melanoma with the immune checkpoint inhibitors, nivolumab and ipilimumab, achieving complete remission of her cancer. She said that throughout her…

Filed under:ConditionsResearch Rheum Tagged with:adverse eventsArthritisCancerImmune checkpoint inhibitorsimmunotherapypatient careRemissionResearchrheumatologystudyTreatment

Checkpoint Inhibitors May Be Retried after Immune Adverse Event, with Close Monitoring

Marilynn Larkin  |  June 13, 2019

NEW YORK (Reuters Health)—After an immune-related adverse event, the risk-reward ratio for an anti-PD-1 (anti-programmed death-1) or anti-PD-L1 (anti-programmed death ligand-1) rechallenge seems to be acceptable if patients are closely monitored, researchers say. “The immune checkpoint inhibitors anti-PD-1 and anti-PD-L1 have proven efficacy in the treatment of many cancers, but patients may experience immune-related adverse…

Filed under:ConditionsDrug Updates Tagged with:anti-PD-1anti-PD-L1Immune checkpoint inhibitorsimmune-related adverse eventsrechallengerisk-reward ratio

Immune-Related Adverse Events with Use of Checkpoint Inhibitors for Immunotherapy of Cancer

Arthritis & Rheumatology  |  March 29, 2017

Introduction: Major advances in the past two decades have enhanced our understanding of the complex interactions between the immune system and cancer cells and their environment. Genetic and epigenetic alterations in tumor cells result in the expression of diverse antigens that can elicit an immune response, primarily mediated by T cells. Immune responses are regulated…

Filed under:Drug UpdatesResearch Rheum Tagged with:Arthritis & RheumatologyCancerCheckpoint InhibitorsimmunotherapyResearch

Ultrasound Provides Insights into Immune Checkpoint Inhibitor‐Induced Inflammatory Arthritis

Elizabeth Hofheinz, MPH, MEd  |  October 12, 2020

Ultrasound may provide unique insights into the effects of immune checkpoint inhibitors on the human body beyond the immune system. Research suggests synovitis and inflammatory tendon involvement are commonly seen in patients with immune checkpoint inhibitor-induced inflammatory arthritis.

Filed under:Conditions Tagged with:ACR Open RheumatologyICI‐induced inflammatory arthritisimmune checkpoint inhibitor (ICI)Immune checkpoint inhibitorsInflammatory arthritisUltrasound

Insights into Immune Checkpoint Inhibitor-Induced Inflammatory Arthritis

Lara C. Pullen, PhD  |  July 29, 2020

Recent research found inflammatory arthritis caused by immune checkpoint inhibitors (ICIs) may become a long-term disease, requiring rheumatology care and immunomodulatory treatment. Some patients experience active inflammatory arthritis years after ICI cessation…

Filed under:Conditions Tagged with:immune checkpoint inhibitor (ICI)Immune checkpoint inhibitorsInflammatory arthritis

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