Certain medications have been associated for decades with the development of drug-induced autoimmunity. New research published in March 2018 in Arthritis & Rheumatology suggests that NETs (neutrophil extracellular traps) are potentially implicated in the mechanisms that lead to drug-induced autoimmunity.1 Peter Grayson, MD, MSc, head of the Vasculitis Translational Research Program at the National Institute…
Search results for: NETosis
Pathophysiology of Gouty Tophi
In a recent study, researchers examined synovial fluid and non-inflamed tophi from the acutely inflamed joints of patients with gout, finding that monosodium urate (MSU) crystals trigger a distinct physiological NETosis pathway that coats MSU crystals in DNA that persists in tissues as gouty tophi…
Professor Shares Findings from 45 Years of Lupus Research
SAN DIEGO—What are the predisposing genes that suggest who will develop active systemic lupus erythematosus and who will stay healthy? Decades of research data help rheumatologists clarify this picture, says Argyrios N. Theofilopoulos, MD, professor of immunology and microbiology at Scripps Research Institute in La Jolla, Calif. At his Nov. 5 lecture at the 2017…
Oxidized Mitochondrial DNA May Contribute to Inflammation in SLE
New research examines how the generation of reactive oxygen species and neutrophil extracellular traps may break down the protective mechanisms of mitochondrial DNA, resulting in NETosis in people with autoimmune disease. They found oxidized mitochondrial DNA may contribute to inflammation in such diseases as systemic lupus erythematosus by upregulating type I interferon signatures…
Rheumatology Researchers Explore Role of Neutrophils in Autoimmunity
SAN FRANCISCO—To unravel the mysteries of how autoimmunity begins in the body and, one day, to interrupt that process, rheumatology researchers are exploring the role of neutrophils, especially when they form and release neutrophil extracellular traps (NETs). At a panel discussion on Nov. 6, 2015, held at the American College of Rheumatology’s Basic Research Conference,…
2014 ACR/ARHP Annual Meeting: Innate Immunity at the Core of Rheumatic Disease
Rheumatology Research Foundation Memorial Lectureship honors work of renowned rheumatologist Stephen Malawista, MD
The ACR/ARHP Annual Meeting: Rheumatoid Arthritis Raises Mortality Risk in Women
Data from Nurses’ Health Study, other clinical trials point to higher risk of respiratory, cardiovascular disease death in women with RA
Lupus Classification Criteria Expanded; Treat-to-Target Approach Gains Support
Rheumatologists at the California Rheumatology Alliance 10th Annual Medical & Scientific Meeting in San Francisco outline disease classification criteria, treat-to-target approach to lupus
Aggregated Neutrophils Limit Inflammation
A new study suggests understanding this antiinflammatory pathway may lead to new immunomodulatory therapy for resolving inflammation
The Granulomatosis of Wegener’s
Delving deeper into the nonvasculitis aspects of the disease