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You are here: Home / Search for "Varicella zoster"

Search results for: Varicella zoster

Varicella Zoster Virus Not Associated with Giant Cell Arteritis Pathogenesis

February 4, 2020 • By Carina Stanton

Researchers suggest antiviral therapy is not appropriate for patients with GCA, based on their study findings and related research…... [Read More]

Filed Under: Conditions, Vasculitis Tagged With: GCA, giant cell arteritis (GCA), varicella zoster virus

Varicella Zoster Virus Downregulates Programmed Death & Promotes Inflammation

November 28, 2016 • By Lara C. Pullen, PhD

A recent study found that the varicella zoster virus downregulates expression of programmed death ligand 1 and major histocompatibility complex 1 in brain fibroblasts, perineurial cells and lung fibroblasts. These effects may lead to persistent inflammation in the vessels and lungs, as well as promote subsequent infection of T cells and the spread of the virus…... [Read More]

Filed Under: Conditions, Systemic Inflammatory Syndromes

Varicella Zoster Virus May Cause Giant Cell Arteritis

August 3, 2015 • By Lara C. Pullen, PhD

Researchers have recently discovered a connection between the varicella zoster virus infection, which causes chicken pox and shingles, and giant cell arteritis…... [Read More]

Filed Under: Conditions, Vasculitis Tagged With: Giant Cell Arteritis, varicella zoster virus, Vasculitis, vasculopathy

Live Herpes Zoster Vaccine Fails to Provide Long-Term Protection in RA Patients on Tofacitinib

April 21, 2020 • By Lisa Rapaport

(Reuters Health)—The live herpes zoster vaccine does not provide reliable long-term protection in rheumatoid arthritis (RA) patients taking tofacitinib, a recent study suggests. Current ACR guidelines conditionally recommend that patients with RA who are 50 years and older be vaccinated against herpes zoster prior to starting therapy with the Janus kinase (JAK) inhibitor tofacitinib or… [Read More]

Filed Under: Conditions, Rheumatoid Arthritis Tagged With: herpes zoster, Rheumatoid Arthritis (RA), shingles, Shingrix, Tofacitinib, vaccine

Zoster Reactivation Risk in Patients Treated with Cyclophosphamide

December 18, 2018 • By Susan Bernstein

Varicella-zoster-virus (VZV) reactivation, which can cause patients to develop herpes zoster (i.e., shingles), occurs more frequently in patients with systemic vasculitis and systemic lupus erythematosus (SLE) who have received intravenous cyclophosphamide than in otherwise healthy adults, according to a retrospective study published in The Journal of Rheumatology by researchers in France.1 The study also shows… [Read More]

Filed Under: Conditions, Research Reviews, SLE (Lupus), Vasculitis Tagged With: cyclophosphamide, herpes zoster, shingles, valacyclovir

Herpes Zoster & Tofacitinib

October 3, 2017 • By Arthritis & Rheumatology

Shingles, also known as herpes zoster (HZ), is a common and sometimes debilitating disease that disproportionately affects elderly individuals and those who are immunocompromised. Patients with rheumatoid arthritis (RA) have a 1.5–2-fold higher risk of developing HZ compared with healthy adults. Treatment with some disease-modifying anti-rheumatic drugs (DMARDs) has been shown to increase this risk…. [Read More]

Filed Under: Biologics & Biosimilars, Drug Updates Tagged With: herpes zoster, Tofacitinib

Herpes Zoster & the Risk of Stroke in Patients with Autoimmune Diseases

January 31, 2017 • By Arthritis & Rheumatology

Herpes zoster (HZ) infection, also known as shingles, is caused by reactivation of latent varicella-zoster virus infection generally acquired decades earlier. This study was designed to test the hypothesis that the incidence of stroke immediately following HZ infection is increased in patients with autoimmune diseases compared with the incidence of stroke at later time points. Results: In patients with autoimmune diseases, incident HZ was associated with as much as a twofold increased risk of stroke. Prompt antiviral therapy was associated with lower incidence of subsequent stroke…... [Read More]

Filed Under: Conditions Tagged With: Arthritis & Rheumatology, Autoimmune disease, herpes zoster, Infection, shingles, stroke

Tofacitinib + Methotrexate: 2-Year Clinical, Radiographic & Safety Outcomes

June 4, 2019 • By Michele B. Kaufman, PharmD, BCGP

In a 24-month clinical trial, tofacitinib proved safe and effective in combination with methotrexate in adult patients with RA…... [Read More]

Filed Under: DMARDs & Immunosuppressives, Drug Updates Tagged With: Methotrexate, Rheumatoid Arthritis (RA), Tofacitinib

Case Report: Lymphocytic Vasculitis of the Central Nervous System

January 17, 2019 • By Gbemisola Olayemi, MD, Evangeline Scopelitis, MD, & Jerald M. Zakem, MD

Vasculitis is a group of chronic inflammatory diseases in which the blood vessel is the target of an immune reaction. They can be secondary to connective tissue disease, idiopathic or due to infection, neoplasm or drugs.1 Primary angiitis of the central nervous system (PACNS) is a rare syndrome characterized by inflammatory cell infiltration and necrosis… [Read More]

Filed Under: Conditions, Vasculitis Tagged With: central nervous system vasculitis, cyclophosphamide, Methylprednisolone, Primary Angiitis of the Central Nervous System

Researchers Fight Cellular Senescence, Low-Grade Inflammation

September 20, 2018 • By Thomas R. Collins

AMSTERDAM—Low-grade inflammation in older adults can impede immune responsiveness, and researchers have shed light on how this happens. They have developed a short-term treatment that blocks inflammation and boosts the immune response, an expert said at EULAR: the Annual European Congress of Rheumatology. The findings were presented in a session on cellular senescence related to… [Read More]

Filed Under: Conditions, Osteoarthritis Tagged With: inflammation, knee osteoarthritis, senescence, senescent

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