Search results for: fever

B Cell Depletion: The Latest Information on Disease Processes, Therapies

Lara C. Pullen, PhD | January 25, 2021

Experts discussed the latest knowledge on B cell disease processes, and what it might mean for future B cell depletion therapies.

Case Report: A Non-Tuberculous Mycobacterial Infection

Bradley Bohman, MD, & Jawad Bilal, MBBS | January 20, 2021

Tumor necrosis factor-α inhibitors (TNFi’s) have emerged as an integral part of therapeutic strategies for several rheumatic diseases. TNF-α is a pro-inflammatory cytokine implicated in the pathogenesis of rheumatoid arthritis (RA), seronegative spondyloarthropathies and inflammatory bowel disease (IBD). It also plays a central role in the immune response to mycobacterial infection. Many biologic agents, particularly…

Case Report: Is It Reactive or IBD-Associated Arthritis?

Hanan Ibrahim, MD, Weixia Guo, MD, & Ayad Alkhatib, MD | January 19, 2021

Reactive arthritis is classically associated with an infectious etiology, such as Salmonella, Yersinia, Campylobacter, Chlamydia or gonorrhea. Clostridium difficile is a rare, and recently recognized, causative agent for this condition.1 Case Presentation The patient is a 21-year-old man with a past medical history significant for hereditary spherocytosis and Crohn’s disease, complicated by an anorectal fistula,…

COVID-19 Immunization Day: It Won’t Be Long Before We Can Hug Again

Charles Radis, DO | January 6, 2021

A young man sits down at my COVID-19 immunization station at Maine Medical Center and stares resolutely ahead, focusing on the far wall. He looks nervous. I make sure the needle and syringe are outside his field of vision. That should help. I pick up a Band-Aid from my box of supplies. It’s a Band-Aid…

The 2020 ACR Review Course: Key Issues Rheumatologists Face

Jason Liebowitz, MD, FACR | December 17, 2020

The ACR Review Course featured eight talks providing a practical review of issues encountered by rheumatologists.

VEXAS: A Newly Identified & Vexing Myeloid-Driven Inflammation

Bryn Nelson, PhD | December 14, 2020

A large, international team of rheumatologists, geneticists, hematologists and other researchers has discovered a severe inflammatory syndrome linked to an acquired genetic mutation in the bone marrow of older men. The X-linked syndrome, they found, is caused by a somatic mutation in myeloid stem cells that hobbles the master regulator of a pathway tasked with…

Pulmonary Adverse Events with Low-Dose Methotrexate

Arthritis & Rheumatology | November 24, 2020

In this large placebo-controlled trial, Sparks et al. examined the predictors and severity of pulmonary adverse events (AEs) in patients taking low-dose MTX. The researchers found that low-dose MTX increased the risk of pulmonary AEs, including possible pneumonitis.

2020 Pediatric Rheumatology Research in Review

Carina Stanton | November 24, 2020

ACR CONVERGENCE 2020—This has been a busy year for research publications covering a number of pediatric rheumatic diseases, including the emerging multi-system inflammatory syndrome (MIS-C) associated with SARS CoV-2. Despite the many challenges brought about by the COVID-19 pandemic, a healthy collection of publications covering a wide range of pediatric rheumatology research topics were published…

Chikungunya Virus May Lead to Long-Term Joint Pain

Linda Childers | November 18, 2020

COVID-19 isn’t the only viral infection on the rise across the globe, so is chikungunya, which can cause arthritis-like symptoms and may lead to long-term joint pain.

What’s the Role of Epstein-Barr Virus Reactivation in Lupus Development?

Larry Beresford | November 12, 2020

A strong association between Epstein-Barr virus (EBV) infections and systemic lupus erythematosus (SLE) has been known since the 1970s. Although the etiology of SLE is not fully established, multiple genetic factors and polymorphisms in genes involved in the immune system have been implicated, with environmental factors also contributing to the development of this complex condition….