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A Unique Breed: RheumMadness 2022 Dalmatian Urate Scouting Report

University of Texas Southwestern Rheumatology Fellowship Program: Kubra Bugdayli, MD; Brett Capel, MD; Yusuf Chao, MD; Melissa DeFoe, MD; Daniel Emesiani, MD; Joad Eseddi, MD; Nagendra Pokala, MD; Komal Patel, MD; Bonnie Bermas, MD; Haidy Galous, MD; Andreas Reimold, MD; & Guillermo Andres Quiceno, MD  |  Issue: May 2022  |  February 14, 2022

Nagendra Pokala, MD, is a first-year fellow in the University of Texas Southwestern Rheumatology Fellowship Program, Dallas.

Komal Patel, MD, is a second-year fellow in the University of Texas Southwestern Rheumatology Fellowship Program, Dallas.

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Bonnie Bermas, MD, is a professor in the Department of Internal Medicine at University of Texas Southwestern Medical Center, Dallas.

Haidy Galous, MD, is an assistant professor in the Department of Internal Medicine at University of Texas Southwestern Medical Center, Dallas.

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Andreas Reimold, MD, is a professor in the Department of Internal Medicine at the University of Texas Southwestern Medical Center, Dallas.

Guillermo Andres Quiceno, MD, is an associate professor in the Department of Internal Medicine and the director of the Rheumatology Fellowship Program at University of Texas Southwestern Medical Center, Dallas.

References

  1. Simkin PA. The dalmatian defect: A hepatic endocrinopathy of urate transport. Arthritis Rheum. 2005 Aug;52(8):2257­–2262.
  2. Voruganti VS, Kent JW Jr, Debnath S, et al. Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans. Front Genet. 2013 Dec 16;4:279.
  3. Ebert K, Ludwig M, Geillinger KE, et al. Reassessment of GLUT7 and GLUT9 as putative fructose and glucose transporters. J Membr Biol. 2017 Apr;250(2):171–182.
  4. Vitart V, Rudan I, Hayward C, et al. SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nat Genet. 2008 Apr;40(4):437–442.
  5. Ruiz A, Gautschi I, Schild L, et al. Human mutations in SLC2A9 (Glut9) affect transport capacity for urate. Front Physiol. 2018 Jun 18;9:476.

Experience All of RheumMadness

During RheumMadness, rheumatology concepts represent teams that compete against each other in a tournament, much like basketball teams do in the NCAA’s March Madness tournament. In a series for The Rheumatologist, readers will get a chance to read the scouting reports. Check out the reports from each region:

Region: Cells

• Anti-NET Antibodies

• Cytokine Networks

• CAR-T Cells

• Pim Kinases

Region: Animal House

• Axolotl Limbs

• Dinosaur SpA

• Dalmatian Urate

• Dog Osteoarthritis

Region: Machines

• AI: JIA Subtypes

• AI: TNFi Response

• DECT in Gout

• PET in LVV

Region: People

• Reproductive Health Guide

• TNFi in Cord Blood

• Increasing +ANA

• False Positive MRI in Axial SpA

Don’t forget to submit your RheumMadness 2022 bracket by March 25. The winner of each match-up is decided by a seven-member Blue Ribbon Panel of rheumatologists. The panel will vote based on which topic they think is most important to patients, providers and researchers—both now and in the future. The more your picks match those of the panel, the more points you get. The tournament results will be released in four rounds from March 26–April 4. Prizes will be given to participants with the top scores in the following categories: 1) attending/APP, 2) fellow and 3) resident/medical student. The prize is a custom RheumMadness coffee mug and a lifetime of bragging rights.

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