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Order in the Inflammatory Mess: RheumMadness 2022 Cytokine Networks Scouting Report

Rheumatology Leadership Team: David Leverenz, MD; Akrithi Udupa, MD; Guy Katz, MD; Lauren He, MD; Ben Kellog, MD; Michael Macklin, MD; Courtney Bair; Matthew Sparks, MD; & Lisa Criscione-Schreiber, MD, MEd  |  Issue: May 2022  |  February 8, 2022


David Leverenz, MD, is assistant professor of medicine at Duke University School of Medicine, Durham, N.C. 

 

Akrithi Udupa, MD, is assistant professor of medicine at MedStar Georgetown University Hospital, Washington, D.C.

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Guy Katz, MD, is a second-year rheumatology fellow at Massachusetts General Hospital, Boston.

Lauren He, MD, is an internal medicine resident at the University of Chicago School of Medicine.

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Ben Kellog, MD, is an internal medicine resident at Duke University School of Medicine, Durham, N.C. 

Michael Macklin, MD, is an internal medicine resident at the University of Pittsburgh Medical Center. 

Courtney Bair is a medical student at Duke University School of Medicine, Durham, N.C.

Matthew Sparks, MD, is an associate professor of medicine at Duke University School of Medicine, Durham, N.C. 

Lisa Criscione-Schreiber, MD, MEd, is a professor of medicine at Duke University School of Medicine, Durham, N.C.

References

  1. Simon Q, Grasseau A, Boudigou M, et al. A proinflammatory cytokine network profile in Th1/type 1 effector B cells delineates a common group of patients in four systemic autoimmune diseases. Arthritis Rheumatol. 2021Aug;73(8):1550–1561.
  2. Schett G, Elewaut D, McInnes IB, et al. How cytokine networks fuel inflammation: Toward a cytokine-based disease taxonomy. Nat Med. 2013 Jul;19(7):822–824.
  3. Christ L, Seitz L, Scholz G, et al. EULAR. A proof-of-concept study to assess the efficacy of tocilizumab monotherapy after ultra-short glucocorticoid administration to treat giant cell arteritis—the GUSTO trial [abstract OP0061]. Ann Rheum Dis. 2021 Jul;80(suppl 1):33.

Experience All of RheumMadness

During RheumMadness, rheumatology concepts represent teams that compete against each other in a tournament, much like basketball teams do in the NCAA’s March Madness tournament. In a series for The Rheumatologist, readers will get a chance to read the scouting reports. Check out the reports from each region:

Region: Cells

• Anti-NET Antibodies

• Cytokine Networks

• CAR-T Cells

• Pim Kinases

Region: Animal House

• Axolotl Limbs

• Dinosaur SpA

• Dalmatian Urate

• Dog Osteoarthritis

Region: Machines

• AI: JIA Subtypes

• AI: TNFi Response

• DECT in Gout

• PET in LVV

Region: People

• Reproductive Health Guide

• TNFi in Cord Blood

• Increasing +ANA

• False Positive MRI in Axial SpA

Don’t forget to submit your RheumMadness 2022 bracket by March 25. The winner of each match-up is decided by a seven-member Blue Ribbon Panel of rheumatologists. The panel will vote based on which topic they think is most important to patients, providers and researchers—both now and in the future. The more your picks match those of the panel, the more points you get. The tournament results will be released in four rounds from March 26–April 4. Prizes will be given to participants with the top scores in the following categories: 1) attending/APP, 2) fellow and 3) resident/medical student. The prize is a custom RheumMadness coffee mug and a lifetime of bragging rights.

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