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Targeting Disease-Causing Cells: RheumMadness 2022 Chimeric Antigen Receptor T Cells Scouting Report

Mass General Hospital Rheumatology Fellowship Program: Guy Katz, MD; Ian Cooley, MD; Duncan Moore, MD; Jacquelyn Nestor, MD, PhD; & Steven Witte, MD, PhD  |  Issue: May 2022  |  February 8, 2022


Guy Katz, MD, is a second-year rheumatology fellow at Massachusetts General Hospital, Boston.

 

Ian Cooley, MD, is a second-year rheumatology fellow at Massachusetts General Hospital, Boston.

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Duncan Moore, MD, is a second-year rheumatology fellow at Massachusetts General Hospital, Boston.

Jacquelyn Nestor, MD, PhD, is a first-year rheumatology fellow at Massachusetts General Hospital, Boston.

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Steven Witte, MD, PhD, is a first-year rheumatology fellow at Massachusetts General Hospital, Boston.

References

  1. Mougiakakos D, Krönke G, Völkl S, et al. CD19-targeted CAR T cells in refractory systemic lupus erythematosus. N Engl J Med. 2021 Aug 5;385(6):567–569.
  2. Orvain C, Boulch M, Bousso P, et al. Is there a place for chimeric antigen receptor T cells in the treatment of chronic autoimmune rheumatic diseases. Arthritis Rheumatol. 2021 Nov;73(11):1954–1965.

Experience All of RheumMadness

During RheumMadness, rheumatology concepts represent teams that compete against each other in a tournament, much like basketball teams do in the NCAA’s March Madness tournament. In a series for The Rheumatologist, readers will get a chance to read the scouting reports. Check out the reports from each region:

Region: Cells

• Anti-NET Antibodies

• Cytokine Networks

• CAR-T Cells

• Pim Kinases

Region: Animal House

• Axolotl Limbs

• Dinosaur SpA

• Dalmatian Urate

• Dog Osteoarthritis

Region: Machines

• AI: JIA Subtypes

• AI: TNFi Response

• DECT in Gout

• PET in LVV

Region: People

• Reproductive Health Guide

• TNFi in Cord Blood

• Increasing +ANA

• False Positive MRI in Axial SpA

Don’t forget to submit your RheumMadness 2022 bracket by March 25. The winner of each match-up is decided by a seven-member Blue Ribbon Panel of rheumatologists. The panel will vote based on which topic they think is most important to patients, providers and researchers—both now and in the future. The more your picks match those of the panel, the more points you get. The tournament results will be released in four rounds from March 26–April 4. Prizes will be given to participants with the top scores in the following categories: 1) attending/APP, 2) fellow and 3) resident/medical student. The prize is a custom RheumMadness coffee mug and a lifetime of bragging rights.

Connect with RheumMadness by subscribing to the podcast and joining the conversation on Twitter, #RheumMadness. Learn on the RheumMadness website.

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